XO/XY和XO/XY/XYY小鼠嵌合体睾丸中XO生殖细胞的命运：小鼠Y染色体上存在精子发生基因的证据。

The fate of XO germ cells in the testes of XO/XY and XO/XY/XYY mouse mosaics: evidence for a spermatogenesis gene on the mouse Y chromosome.

作者信息

Levy E R, Burgoyne P S

出版信息

Cytogenet Cell Genet. 1986;42(4):208-13. doi: 10.1159/000132280.

Abstract

A cytogenetic and histological study of nine XO/XY or XO/XY/XYY mosaic mice revealed that XO germ cells were selectively eliminated from the spermatogenic epithelium. Although the XO contribution to the bone marrow in seven mice exceeded 50%, in only two cases were significant numbers of dividing XO spermatogonia present. These XO germ cells only occasionally progressed to meiosis and then degenerated prior to first meiotic metaphase. It was concluded that the mouse Y chromosome carries a "spermatogenesis gene" (or genes) which acts autonomously in the germ cells.

摘要

对9只XO/XY或XO/XY/XYY嵌合小鼠进行的细胞遗传学和组织学研究表明，XO生殖细胞从生精上皮中被选择性清除。尽管7只小鼠中XO对骨髓的贡献超过50%，但只有两例存在大量正在分裂的XO精原细胞。这些XO生殖细胞仅偶尔进入减数分裂，然后在第一次减数分裂中期之前退化。研究得出结论，小鼠Y染色体携带一个“精子发生基因”（或多个基因），该基因在生殖细胞中自主发挥作用。