Osouli-Tabrizi Shirin, Mehdizadeh Amir, Naghdi Mina, Sanaat Zohreh, Vahed Nafiseh, Farshbaf-Khalili Azizeh
Department of Midwifery, Faculty of Nursing and Midwifery Tabriz University of Medical Sciences Tabriz Iran.
Hematology and Oncology Research Center Tabriz University of Medical Sciences Tabriz Iran.
Food Sci Nutr. 2023 May 22;11(8):4355-4371. doi: 10.1002/fsn3.3409. eCollection 2023 Aug.
This study aimed to systematically evaluate the impact of omega-3 fatty acids on the health outcomes of women with breast cancer in electronic databases (PubMed, Scopus, ProQuest, Web of Science, and Cochrane Library) for interventional studies. The risk of bias and the quality of the included articles were assessed by Cochrane Collaboration Handbook guidance. The statistical analyses were not conducted because of the heterogeneity of the included studies. Of 3676 identified articles, 11 articles were included in this study. The majority of the included studies were not of high quality. Median progression time and overall survival significantly improved. Additionally, surgical site healing complications and infection rates decreased. There was a significant decrease in perceived stress, sleep disturbance, depression, pain, joint stiffness, and fatigue throughout the intervention. Moreover, omega-3 fatty acids consumption significantly increased the total serum omega-3, EPA, and DHA, and decreased the omega-6: omega-3 ratio, total leukocytes, lymphocytes, leptin, and CRP, accordingly. Mild gastrointestinal symptoms were reported in only two studies without clinically relevant adverse events. Omega-3 fatty acids may cause improvement in physical, mental, and some inflammatory and metabolic indices during treatment or posttreatment course of breast cancer patients. Due to the possibility of free radical formation, omega-3 FAs supplementation and consumption must be done very carefully.
本研究旨在系统评估ω-3脂肪酸对电子数据库（PubMed、Scopus、ProQuest、Web of Science和Cochrane图书馆）中乳腺癌女性健康结局的影响，以进行干预性研究。按照Cochrane协作手册指南评估纳入文章的偏倚风险和质量。由于纳入研究的异质性，未进行统计分析。在检索到的3676篇文章中，本研究纳入了11篇。纳入的研究大多质量不高。中位进展时间和总生存期显著改善。此外，手术部位愈合并发症和感染率降低。在整个干预过程中，感知压力、睡眠障碍、抑郁、疼痛、关节僵硬和疲劳均显著降低。此外，摄入ω-3脂肪酸显著提高了血清总ω-3、二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）水平，并相应降低了ω-6与ω-3的比值、总白细胞、淋巴细胞、瘦素和C反应蛋白（CRP）。仅有两项研究报告了轻微的胃肠道症状，且无临床相关不良事件。ω-3脂肪酸可能会改善乳腺癌患者治疗期间或治疗后的身体、心理以及一些炎症和代谢指标。由于可能会形成自由基，补充和摄入ω-3脂肪酸必须非常谨慎。
