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实体肿瘤恶性肿瘤所致获得性凝血因子VIII抑制剂

Acquired factor VIII inhibitor caused by solid tumor malignancy.

作者信息

de Bear Olivia, McLean Karen, Siedel Jean, Rolston Aimee

机构信息

Gynecologic Oncology Division, Department of Obstetrics and Gynecology, Michigan Medicine, 1500 East Medical Center Drive, Ann Arbor, MI 48109, United States.

Department of Gynecologic Oncology and Department of Pharmacology & Therapeutics, Roswell Park Comprehensive Cancer Center, Elm & Carlton Streets, Buffalo, NY 14263, United States.

出版信息

Gynecol Oncol Rep. 2023 Jun 7;48:101217. doi: 10.1016/j.gore.2023.101217. eCollection 2023 Aug.

DOI:10.1016/j.gore.2023.101217
PMID:37576357
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10422097/
Abstract

•Factor VIII inhibitor can be acquired in gynecologic and other malignancies.•The disorder can develop along any timeline of malignancy diagnosis.•Common presentation is uncontrolled bleeding not managed by common interventions.•Treatment requires hemostatic control and an immunosuppressive regimen.

摘要

•获得性血友病A可发生于妇科及其他恶性肿瘤中。

•该疾病可在恶性肿瘤诊断后的任何时间出现。

•常见表现为常规干预措施无法控制的出血。

•治疗需要实现止血控制并采用免疫抑制方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddb3/10422097/f8db5222ca01/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddb3/10422097/f8db5222ca01/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddb3/10422097/f8db5222ca01/gr1.jpg

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本文引用的文献

1
International recommendations on the diagnosis and treatment of acquired hemophilia A.国际上关于获得性血友病 A 的诊断和治疗建议。
Haematologica. 2020 Jul;105(7):1791-1801. doi: 10.3324/haematol.2019.230771. Epub 2020 May 7.
2
Management of coagulation factor VIII (FVIII) inhibitors.FVIII 抑制剂的管理。
Thromb Res. 2019 Sep;181 Suppl 1:S60-S61. doi: 10.1016/S0049-3848(19)30369-X.
3
Acquired haemophilia in cancer: A systematic and critical literature review.癌症相关性获得性血友病：系统且批判性文献回顾。
Haemophilia. 2018 Jan;24(1):43-56. doi: 10.1111/hae.13355. Epub 2017 Sep 27.
4
Demographic and clinical data in acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2).获得性血友病 A 的人口统计学和临床数据：来自欧洲获得性血友病登记处（EACH2）的结果。
J Thromb Haemost. 2012 Apr;10(4):622-31. doi: 10.1111/j.1538-7836.2012.04654.x.
5
Acquired hemophilia: a case report of 2 patients with acquired factor VIII inhibitor treated with rituximab plus a short course of steroid and review of the literature.获得性血友病：2例接受利妥昔单抗联合短期类固醇治疗的获得性凝血因子VIII抑制物患者的病例报告及文献复习
Clin Appl Thromb Hemost. 2007 Oct;13(4):443-8. doi: 10.1177/1076029607303777.
6
Inhibitors against factor VIII in patients with cancer. Analysis of 41 patients.癌症患者中针对凝血因子VIII的抑制剂。41例患者的分析。
Cancer. 2001 Mar 15;91(6):1067-74. doi: 10.1002/1097-0142(20010315)91:6<1067::aid-cncr1101>3.0.co;2-4.
7
Solid tumors and factor VIII antibodies.
Thromb Haemost. 1999 Sep;82(3):1005-7.