Zeng Junchao, Li Jing, Liu Bo, Yu Qun, Lei Ziqiao, Yang Fan, Ding Mingyue, Fan Wenliang
Medical Ultrasound Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Advanced Bio-Medical Imaging Facility, Huazhong University of Science and Technology, Wuhan 430074, China.
Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Bioengineering (Basel). 2025 Jun 5;12(6):619. doi: 10.3390/bioengineering12060619.
Unilateral sudden sensorineural hearing loss (SSHL) presents substantial clinical challenges owing to its abrupt onset and multifactorial, poorly understood etiology. This study investigates the static and dynamic changes in local brain connectivity using regional homogeneity (ReHo) analyses in 102 SSHL patients and 73 healthy controls. A static ReHo analysis reveals pronounced disruptions in local synchronization within motor and cognitive-related brain regions in SSHL patients compared to controls. A dynamic ReHo analysis uncovers increased temporal variability, particularly in frontal regions, indicating potential adaptive neural plasticity to auditory deficits through enhanced neural plasticity. The correlation analyses further associate these neural changes with clinical parameters, highlighting the significant positive correlations between static ReHo in the left precentral gyrus and tinnitus severity (R = 0.39, < 0.001), as well as the negative correlations between dynamic ReHo in the middle frontal gyrus and the duration of hearing loss (R = -0.35, < 0.001). These findings underscore the complex interplay between static neural dysregulation and dynamic adaptive mechanisms in the pathophysiology of SSHL. Emphasizing dynamic metrics, our study provides a novel temporal perspective on how the brain reorganizes in response to acute sensory loss.
单侧突发性感音神经性听力损失（SSHL）因其突然发作以及病因多因素且难以理解，带来了重大的临床挑战。本研究使用局部一致性（ReHo）分析，对102例SSHL患者和73名健康对照者进行研究，以调查局部脑连接的静态和动态变化。静态ReHo分析显示，与对照组相比，SSHL患者运动和认知相关脑区的局部同步性明显中断。动态ReHo分析发现时间变异性增加，尤其是在额叶区域，表明可能通过增强神经可塑性对听觉缺陷产生适应性神经可塑性。相关性分析进一步将这些神经变化与临床参数相关联，突出了左侧中央前回静态ReHo与耳鸣严重程度之间的显著正相关（R = 0.39，<0.001），以及额中回动态ReHo与听力损失持续时间之间的负相关（R = -0.35，<0.001）。这些发现强调了SSHL病理生理学中静态神经调节异常与动态适应性机制之间的复杂相互作用。强调动态指标，我们的研究为大脑如何响应急性感觉丧失进行重组提供了一个新的时间视角。
