Muhammad Naeem, Sonkusare Saurabh, Ding Qiong, Wang Linbin, Mandali Alekhya, Zhao Yi Jie, Sun Bomin, Li Dianyou, Voon Valerie
Department of Neurosurgery, Centre for Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom.
Front Hum Neurosci. 2023 Jul 27;17:1181635. doi: 10.3389/fnhum.2023.1181635. eCollection 2023.
Deep brain stimulation (DBS) studies in Parkinson's Disease (PD) targeting the subthalamic nucleus (STN) have characterized its spectral properties across cognitive processes. In emotional evaluation tasks, specific alpha frequency (8-12 Hz) event-related de-synchronization (ERD) (reduced power) has been demonstrated. The time-locked stimulation of STN relative to stimuli onset has shown subjective positive valence shifts with 10 Hz but not with 130 Hz. However, neurophysiological effects of stimulation on power modulation have not been investigated. We aim to investigate effects of acute stimulation of the right STN on concurrent power modulation in the contralateral STN and frontal scalp EEG. From our previous study, we had a strong hypothesis that negative imagery without stimulation would be associated with alpha ERD; negative imagery with 130 Hz stimulation would be also associated with alpha ERD given the lack of its effect on subjective valence ratings; negative imagery with 10 Hz stimulation was to be associated with enhanced alpha power given the shift in behavioral valence ratings.
Twenty-four subjects with STN DBS underwent emotional picture-viewing tasks comprising neutral and negative pictures. In a subset of these subjects, the negative images were associated with time-locked acute stimulation at either 10 or 130 Hz. Power of signals was estimated relative to the baseline and subjected to non-parametric statistical testing.
As hypothesized, in 130 Hz stimulation condition, we show a decrease in alpha power to negative vs. neutral images irrespective of stimulation. In contrast, this alpha power decrease was no longer evident in the negative 10 Hz stimulation condition consistent with a predicted increase in alpha power. Greater beta power in the 10 Hz stimulation condition along with correlations between beta power across the 10 Hz stimulation and unstimulated conditions suggest physiological and cognitive generalization effects.
Acute alpha-specific frequency stimulation presumably was associated with a loss of this expected decrease or desynchronization in alpha power to negative images suggesting the capacity to facilitate the synchronization of alpha and enhance power. Acute time-locked stimulation has the potential to provide causal insights into the spectral frequencies and temporal dynamics of emotional processing.
针对帕金森病（PD）丘脑底核（STN）的脑深部电刺激（DBS）研究已经描述了其在认知过程中的频谱特性。在情绪评估任务中，已经证明了特定的阿尔法频率（8 - 12赫兹）事件相关去同步化（ERD）（功率降低）。相对于刺激开始，STN的锁时刺激已显示10赫兹时主观正性效价发生变化，而130赫兹时则未发生变化。然而，刺激对功率调制的神经生理效应尚未得到研究。我们旨在研究右侧STN的急性刺激对同侧STN和额叶头皮脑电图同步功率调制的影响。根据我们之前的研究，我们有一个强烈的假设，即无刺激的负性意象会与阿尔法ERD相关；鉴于130赫兹刺激对主观效价评分没有影响，130赫兹刺激的负性意象也会与阿尔法ERD相关；鉴于行为效价评分的变化，10赫兹刺激的负性意象会与增强的阿尔法功率相关。
24名接受STN DBS的受试者进行了包括中性和负性图片的情绪图片观看任务。在这些受试者的一个子集中，负性图像与10或130赫兹的锁时急性刺激相关。信号功率相对于基线进行估计，并进行非参数统计测试。
如假设所示，在130赫兹刺激条件下，无论是否有刺激，我们都观察到负性图像与中性图像相比阿尔法功率降低。相比之下，在负性10赫兹刺激条件下，这种阿尔法功率降低不再明显，这与预测的阿尔法功率增加一致。10赫兹刺激条件下更大的贝塔功率以及10赫兹刺激条件与未刺激条件下贝塔功率之间的相关性表明存在生理和认知泛化效应。
急性阿尔法特定频率刺激可能与负性图像阿尔法功率预期降低或去同步化的丧失相关，这表明其有促进阿尔法同步化和增强功率的能力。急性锁时刺激有可能为情绪处理的频谱频率和时间动态提供因果见解。
