Department of Biochemistry and Molecular Biology, Basic Medical College, Shanxi Medical University, Taiyuan, China.
Department of Endocrinology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, China.
Front Endocrinol (Lausanne). 2023 Jul 27;14:1193181. doi: 10.3389/fendo.2023.1193181. eCollection 2023.
The clinical correlation between adipokines levels in the blood and the incidence of senile osteoporosis (SOP) has not been clearly studied. We conducted this meta-analysis to elucidate the relationship between three common adipokines levels (leptin, adiponectin, and chemerin) and the incidence of SOP.
We searched databases such as CNKI, CBM, VIP, Wanfang, PubMed, Web of Science, Embase, and the Cochrane Library to collect articles published since the establishment of the database until July 30, 2022.
In total, 11 studies met the selection criteria. Our meta-analysis showed that serum leptin levels were significantly lower (mean difference [MD], -2.53, 95% CI: -3.96 to -1.10, 96%), chemerin levels were significantly higher (MD, 30.06, 95% CI: 16.71 to 43.40, 94%), and adiponectin levels were not significantly different (MD, -0.55, 95% CI: -2.26 to 1.17, = 0.53, 98%) in SOP patients compared with healthy older individuals with normal bone mineral density (BMD). In addition, correlation analysis showed that leptin levels were positively correlated with lumbar bone mineral density (LBMD) (r = 0.36) and femoral bone mineral density (FBMD) (r = 0.38), chemerin levels were negatively correlated with LBMD (r = -0.55) and FBMD (r = -0.48), and there were significant positive correlations between leptin and adiponectin levels and body mass index (BMI) (r = 0.91 and 0.97).
The likelihood of having SOP was higher in older individuals with low levels of leptin and higher levels of chemerin. In addition, BMI was somewhat lower with low levels of leptin and adiponectin.
https://www.crd.york.ac.uk/prospero/, identifier CRD42022356469.
脂肪因子在血液中的水平与老年性骨质疏松症（SOP）的发生率之间的临床相关性尚未得到明确研究。我们进行了这项荟萃分析，以阐明三种常见脂肪因子（瘦素、脂联素和趋化素）水平与 SOP 发生率之间的关系。
我们检索了中国知网、中国生物医学文献数据库、维普、万方、PubMed、Web of Science、Embase 和 Cochrane 图书馆等数据库，收集了自数据库建立以来至 2022 年 7 月 30 日发表的文章。
共有 11 项研究符合选择标准。我们的荟萃分析表明，SOP 患者的血清瘦素水平显著降低（均差[MD]，-2.53，95%置信区间：-3.96 至-1.10，96%），趋化素水平显著升高（MD，30.06，95%置信区间：16.71 至 43.40，94%），而脂联素水平差异无统计学意义（MD，-0.55，95%置信区间：-2.26 至 1.17， = 0.53，98%）与正常骨密度（BMD）的健康老年个体。此外，相关性分析表明，瘦素水平与腰椎骨密度（LBMD）（r = 0.36）和股骨骨密度（FBMD）（r = 0.38）呈正相关，趋化素水平与 LBMD（r = -0.55）和 FBMD（r = -0.48）呈负相关，瘦素和脂联素水平与体重指数（BMI）呈显著正相关（r = 0.91 和 0.97）。
瘦素水平较低、趋化素水平较高的老年个体发生 SOP 的可能性更高。此外，瘦素和脂联素水平较低时 BMI 也略有降低。
https://www.crd.york.ac.uk/prospero/，标识符 CRD42022356469。
