Anwer J, Mehrotra N K
Drug Chem Toxicol. 1986;9(2):171-83. doi: 10.3109/01480548608998273.
In the present investigation the effect of Benzo(a)pyrene (BP) and Nickel chloride, quite often identified in crude and refined or waste oil, when injected in combination, was investigated on developing chick embryos after exposing them through yolk sac route on 6th day of incubation. Exposure to this combination in different doses resulted in no new deformities other than those experienced in BP treated chick embryos. The mortality and malformations experienced in the chick embryos exposed to BP alone and NiCl2 alone were seen to be added when both the chemicals were simultaneously inoculated into the same chick eggs.
在本研究中，对孵化第6天的发育中鸡胚经卵黄囊途径暴露于苯并(a)芘（BP）和氯化镍（经常在原油、精炼油或废油中发现）的联合作用进行了研究。以不同剂量暴露于这种联合物，除了BP处理的鸡胚出现的畸形外，未导致新的畸形。当将这两种化学物质同时接种到同一鸡胚蛋中时，单独暴露于BP和单独暴露于NiCl₂的鸡胚所经历的死亡率和畸形率出现相加情况。
