Magras I N, Kotsaki-Kovatsi V P, Kovatsis A, Adamidou L
Laboratory of Anatomy and Histology, Veterinary Faculty, Aristotelian, University of Thessaloniki, Macedonia, Greece.
Vet Hum Toxicol. 1993 Oct;35(5):434-5.
The effect of a mixture of scopolamine and hyoscyamine (98:2) on developing chick embryos was investigated. The embryos were exposed at 2 stages of development to various doses of this mixture via yolk sac injection. This resulted in deaths at different stages of prenatal development, as well as various malformations and reduction deformities. These findings suggest that the studied mixture has a teratogenic effect when injected into the yolk sac of developing chick embryos.
研究了东莨菪碱和莨菪碱混合物（98:2）对发育中的鸡胚的影响。通过卵黄囊注射，在胚胎发育的两个阶段将胚胎暴露于不同剂量的该混合物中。这导致产前发育的不同阶段出现死亡，以及各种畸形和发育不全。这些发现表明，当将所研究的混合物注入发育中的鸡胚卵黄囊中时具有致畸作用。
