Anwer J, Mehrotra N K
Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, India.
Toxicol Lett. 1988 Mar;40(3):195-201. doi: 10.1016/0378-4274(88)90041-0.
The effect of benzo[a]pyrene (BP), an established carcinogen, on developing chick embryos was investigated. The embryos were exposed in different stages of development to various doses of BP via the yolk sac route. This resulted in retarded growth, as reflected by lower embryonic body weight, reduced crown-rump length and bill length. Abnormal survivors showed remarkably twisted legs with shortening of the bones, abdominal oedema, haematomas, blisters and a short neck. These findings suggest that BP is a teratogen when injected via this route, and the 'oedema syndrome' is a possible mechanism causing teratogenic effects in developing chick embryos when treated with BP.
研究了公认的致癌物苯并[a]芘（BP）对发育中的鸡胚的影响。通过卵黄囊途径，使处于不同发育阶段的胚胎暴露于不同剂量的BP。这导致了生长迟缓，表现为胚胎体重降低、顶臀长度和喙长减小。异常存活者表现出腿部明显扭曲、骨骼缩短、腹部水肿、血肿、水泡和颈部短小。这些发现表明，经此途径注射时BP是一种致畸剂，“水肿综合征”可能是在用BP处理发育中的鸡胚时导致致畸作用的一种机制。
