Dong Run, Liu Wei, Weng Li, Yin Peng, Peng Jinmin, Chen Yan, Li Shan, Wang Chunyao, Jiang Wei, Hu Xiaoyun, Du Bin, Zhou Maigeng
Medical Intensive Care Unit, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Ann Intensive Care. 2023 Aug 14;13(1):71. doi: 10.1186/s13613-023-01166-1.
The scarcity of sepsis epidemiologic data from most low- and middle-income countries (LMICs) hampered estimation of regional and global burden of the disease, and provided limited guidance for policy makers. We aimed to characterize and analyze the temporal trends of sepsis-related mortality in China, by population groups, underlying causes of death, geographic regions, and sociodemographic index (SDI) levels.
Sepsis-related deaths were identified from the National Mortality Surveillance System (NMSS) of China from 2006 to 2020. Trends of sepsis-related mortality and years of life lost (YLLs), stratified by age, sex, underlying diseases, and regions were analyzed using the Jointpoint regression analysis. We investigated the association of SDI with trends of sepsis-related mortality.
In 2020, sepsis was estimated to be responsible for 986,929 deaths and 17.1 million YLLs in China. Age-standardized sepsis-related mortality significantly declined from 130.2 (95%CI, 129.4-131) per 100,000 population in 2006 to 76.6 (76.3-76.9) in 2020. Age-standardized YLLs decreased from 2172.7 (2169.4-2176) per 100,000 population in 2006 to 1271 (1269.8-1272.2) in 2020. Substantial variations of sepsis-related mortality and YLLs were observed between population groups and regions, with higher burden in males, the elderly, and western China. An inverse relation was noted between SDI and sepsis-related mortality or YLLs.
Despite declining trends of age-standardized mortality and YLLs of sepsis in China, significant disparities between population groups and regions highlight a need for targeted policies and measures to close the gaps and improve the outcome of sepsis.
大多数低收入和中等收入国家（LMICs）缺乏脓毒症流行病学数据，这阻碍了对该疾病区域和全球负担的评估，也为政策制定者提供了有限的指导。我们旨在按人群、潜在死因、地理区域和社会人口指数（SDI）水平，描述和分析中国脓毒症相关死亡率的时间趋势。
从中国国家死亡监测系统（NMSS）中识别出2006年至2020年期间与脓毒症相关的死亡病例。使用Joinpoint回归分析，分析了按年龄、性别、潜在疾病和地区分层的脓毒症相关死亡率和寿命损失年数（YLLs）的趋势。我们研究了SDI与脓毒症相关死亡率趋势之间的关联。
2020年，在中国，估计脓毒症导致986,929例死亡和1710万寿命损失年。年龄标准化的脓毒症相关死亡率从2006年的每10万人130.2（95%CI，129.4 - 131）显著下降到2020年的76.6（76.3 - 76.9）。年龄标准化的寿命损失年数从2006年的每10万人2172.7（2169.4 - 2176）下降到2020年的1271（1269.8 - 1272.2）。在人群组和地区之间观察到脓毒症相关死亡率和寿命损失年数存在显著差异，男性、老年人和中国西部的负担更高。注意到SDI与脓毒症相关死亡率或寿命损失年数之间呈负相关。
尽管中国脓毒症的年龄标准化死亡率和寿命损失年数呈下降趋势，但人群组和地区之间的显著差异凸显了需要有针对性的政策和措施来缩小差距并改善脓毒症的治疗结果。
