Department of Orthodontics, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, Shandong, People's Republic of China.
Department of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao, China.
Lasers Med Sci. 2023 Aug 14;38(1):184. doi: 10.1007/s10103-023-03835-w.
The aim of this study is to systematically summarize the available evidence regarding low-level laser therapy (LLLT) speed-up effect on dental alignment in comprehensive orthodontic treatment. An extensive electronic search was conducted in PubMed, ScienceDirect, Cochrane, Web of Science, and Scopus up to February 20, 2023. The Cochrane risk of bias tool and the Newcastle-Ottawa Quality Assessment Form were used by two authors independently to assess the risk of bias (RoB). Statistical analysis was performed by Review Manager 5.3. The eight eligible trials were reviewed and included in qualitative synthesis. Four studies reported the overall time of leveling and alignment (OLAT, days), enabling a synthesizing of the data. The meta-analysis results showed that LLLT significantly reduced the overall time of leveling and alignment compared to control group (MD=-30.36, 95% CI range -41.50 to -19.22, P<0.0001), with moderate heterogeneity (χ2=4.10, P=0.25, I=27%). Based on the data available, statistically significant evidence with moderate risk of bias suggests that LLLT may have a positive effect on accelerating dental alignment. However, due to the differences in intervention strategy and evaluating method, the conclusions should be interpreted with caution.
本研究旨在系统总结低水平激光疗法（LLLT）在综合正畸治疗中加速牙齿矫正效果的现有证据。我们对 PubMed、ScienceDirect、Cochrane、Web of Science 和 Scopus 进行了广泛的电子检索，检索时间截至 2023 年 2 月 20 日。两位作者独立使用 Cochrane 偏倚风险工具和 Newcastle-Ottawa 质量评估表评估偏倚风险（RoB）。统计分析由 Review Manager 5.3 进行。审查了八项合格试验，并进行了定性综合。四项研究报告了总平层和排齐时间（OLAT，天），使数据得以综合。Meta 分析结果表明，与对照组相比，LLLT 显著缩短了平层和排齐的总时间（MD=-30.36，95%CI 范围-41.50 至-19.22，P<0.0001），存在中度异质性（χ2=4.10，P=0.25，I=27%）。基于现有数据，具有中度偏倚风险的统计学显著证据表明，LLLT 可能对加速牙齿矫正有积极影响。然而，由于干预策略和评估方法的差异，结论应谨慎解释。
