Itakura M, Kunika K, Yamashita K
Endocrinol Jpn. 1986 Apr;33(2):133-41. doi: 10.1507/endocrj1954.33.133.
The synthesis of labile hemoglobin A1 in vivo was studied in subjects with non-insulin dependent diabetes mellitus, impaired and normal glucose tolerance. The labile hemoglobin A1 index defined as delta labile hemoglobin A1 divided by delta plasma glucose at 30 min after oral glucose load, representing the rate of labile hemoglobin A1 synthesis in vivo, was low in diabetic subjects and high in normal subjects, showing an inverse correlation with the amount of preexisting hemoglobin A1. The study on the synthesis of labile hemoglobin A1 in vitro showed a lower initial rate of synthesis and a smaller increase in labile hemoglobin A1 at saturation in red blood cells from diabetic subjects with a relatively large amount of preexisting hemoglobin A1, as opposed to red blood cells from normal subjects. Although the further study is necessary in which delta plasma glucose levels are kept relatively constant in each of 3 groups by glucose-clamp methods, our data suggest that the synthesis of labile hemoglobin A1 is limited in vivo and in vitro in diabetic subjects by the preexisting hemoglobin A1 due to the saturability of its synthesis.
在非胰岛素依赖型糖尿病、糖耐量受损及糖耐量正常的受试者体内，对不稳定血红蛋白A1的合成进行了研究。不稳定血红蛋白A1指数定义为口服葡萄糖负荷后30分钟时不稳定血红蛋白A1的变化量除以血浆葡萄糖的变化量，代表体内不稳定血红蛋白A1的合成速率，该指数在糖尿病受试者中较低，在正常受试者中较高，与预先存在的血红蛋白A1的量呈负相关。对不稳定血红蛋白A1体外合成的研究表明，与正常受试者的红细胞相比，预先存在相对大量血红蛋白A1的糖尿病受试者的红细胞，其初始合成速率较低，且在饱和时不稳定血红蛋白A1的增加量较小。尽管有必要通过葡萄糖钳夹法对三组受试者的血浆葡萄糖变化水平进行更深入研究，使每组受试者的血浆葡萄糖变化水平保持相对恒定，但我们的数据表明，由于不稳定血红蛋白A1合成的饱和性，预先存在的血红蛋白A会在体内和体外限制糖尿病受试者体内不稳定血红蛋白A1的合成。
