Goebel F D, Füessl H, Dörfler H, Kolmar C
Res Exp Med (Berl). 1981;179(2):133-40. doi: 10.1007/BF01851981.
Haemoglobin A1 (Hb A1) is becoming a routine parameter for monitoring diabetic metabolism. Although widely used, the kinetic relationship between glucose concentration and Hb A1 value is not clarified yet. In vivo biosynthesis of Hb A1 was studied in 30 patients during an oral glucose tolerance test. Ten diabetics received an i.v. injection of 0.5 g glucose/kg, 20 healthy students and infusion of 1.0 g and 1.5 g glucose/kg and hour for 6h, and six volunteers 2.0 g/kg and hour. A parallel increase and decrease of serum glucose levels and Hb A1 could be demonstrated beginning a few minutes after administration of glucose. These acute changes of Hb A1 are closely related to fluctuation of serum glucose probably representing the formation and dissociation of the labile aldimine-linkage between haemoglobin and glucose. Severe hyperglycaemia of 6 h duration is not sufficient to cause an elevation of stable glycohaemoglobin.
血红蛋白A1（Hb A1）正成为监测糖尿病代谢的常规参数。尽管其应用广泛，但葡萄糖浓度与Hb A1值之间的动力学关系尚未明确。在口服葡萄糖耐量试验期间，对30例患者的Hb A1体内生物合成进行了研究。10名糖尿病患者静脉注射0.5 g葡萄糖/千克，20名健康学生以1.0 g和1.5 g葡萄糖/千克·小时的速率输注葡萄糖，持续6小时，6名志愿者以2.0 g/千克·小时的速率输注。在给予葡萄糖后几分钟开始，可以证明血清葡萄糖水平和Hb A1呈平行升高和降低。Hb A1的这些急性变化与血清葡萄糖波动密切相关，可能代表血红蛋白与葡萄糖之间不稳定醛亚胺键的形成和解离。持续6小时的严重高血糖不足以导致稳定糖化血红蛋白升高。
