尿致突变性作为食物烹饪过程中形成的膳食诱变剂暴露指标。
Urine mutagenicity as an indicator of exposure to dietary mutagens formed during cooking of foods.
作者信息
Baker R S, Darnton-Hill I, Bonin A M, Arlauskas A, Braithwaite C, Wootton M, Truswell A S
出版信息
Environ Health Perspect. 1986 Aug;67:147-52. doi: 10.1289/ehp.8667147.
Abstract
Studies were undertaken with individuals fed fried bacon meals to determine whether fruit or vegetables, ingested along with bacon, modified uptake and subsequent excretion of bacon mutagen(s). Urinary mutagenic activity was significant in those who had consumed bacon or mixed bacon/vegetable or bacon/fruit meals within the previous 2 to 3 hr period. Although urine activity varied by a factor of 4 among 15 subjects who consumed different meals, there was no evidence from this investigation that fruit or vegetables contributed to the inherent variability in total urinary mutagenic activity. However, some differences in excretion kinetics may be attributable to vegetable or fruit supplements in mixed meals.
摘要
对食用煎培根餐的个体进行了研究，以确定与培根一起摄入的水果或蔬菜是否会改变培根诱变剂的吸收及随后的排泄。在过去2至3小时内食用了培根、培根/蔬菜混合餐或培根/水果混合餐的人的尿液诱变活性显著。尽管在15名食用不同餐食的受试者中，尿液活性相差4倍，但这项调查没有证据表明水果或蔬菜会导致总尿液诱变活性的固有变异性。然而，排泄动力学的一些差异可能归因于混合餐中的蔬菜或水果补充剂。
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2
Non-mutagenicity of urine from coffee drinkers compared with that from cigarette smokers.咖啡饮用者尿液与吸烟者尿液的非诱变性比较。
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3
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Ann Occup Hyg. 1981;24(1):77-92. doi: 10.1093/annhyg/24.1.77.
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7
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8
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