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1
Urine mutagenicity as an indicator of exposure to dietary mutagens formed during cooking of foods.尿致突变性作为食物烹饪过程中形成的膳食诱变剂暴露指标。
Environ Health Perspect. 1986 Aug;67:147-52. doi: 10.1289/ehp.8667147.
2
Detection of mutagenic activity in human urine following fried pork or bacon meals.
Cancer Lett. 1982 May-Jun;16(1):81-9. doi: 10.1016/0304-3835(82)90094-5.
3
Urinary mutagens in humans after fried pork and bacon meals.
Cancer Lett. 1984 Apr;22(3):275-80. doi: 10.1016/0304-3835(84)90163-0.
4
Detection of genotoxicity in fried bacon by the Salmonella/mammalian microsome mutagenicity assay.用沙门氏菌/哺乳动物微粒体诱变试验检测油炸培根中的遗传毒性。
Food Chem Toxicol. 1983 Jun;21(3):319-23. doi: 10.1016/0278-6915(83)90067-4.
5
Urinary mutagenesis and fried red meat intake: influence of cooking temperature, phenotype, and genotype of metabolizing enzymes in a controlled feeding study.尿致突变性与油炸红肉摄入量:在一项对照喂养研究中烹饪温度、代谢酶表型和基因型的影响
Environ Mol Mutagen. 2004;43(1):53-74. doi: 10.1002/em.10205.
6
Influence of fried meat and fiber on cytochrome P-450 mediated activity and excretion of mutagens in rats.油炸肉类和纤维对大鼠细胞色素P-450介导的诱变剂活性及排泄的影响。
Mutat Res. 1988 Apr;204(4):553-63. doi: 10.1016/0165-1218(88)90058-4.
7
Mutagenicity of human urine after the consumption of fried salted salmon.食用油炸咸鱼后人类尿液的致突变性。
Food Chem Toxicol. 1987 Feb;25(2):147-53. doi: 10.1016/0278-6915(87)90148-7.
8
Dietary factors affecting the urinary mutagenicity assay system. I. Detection of mutagenic activity in human urine following a fried beef meal.影响尿液诱变活性检测系统的饮食因素。I. 食用煎牛排餐后人体尿液中诱变活性的检测。
Mutat Res. 1985 May;149(3):365-74. doi: 10.1016/0027-5107(85)90153-8.
9
Effect of cooking methods on the mutagenicity of food and on urinary mutagenicity of human consumers.烹饪方法对食物致突变性及人类食用者尿液致突变性的影响。
Food Chem Toxicol. 1989 Oct;27(10):657-66. doi: 10.1016/0278-6915(89)90120-8.
10
Urinary mutagenicity in vegetarians and people on a mixed-western diet.素食者和西方混合饮食者的尿液致突变性。
Zentralbl Hyg Umweltmed. 1992 Mar;192(6):494-508.

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Reduction in Exposure to Selected Harmful and Potentially Harmful Constituents Approaching Those Observed Upon Smoking Abstinence in Smokers Switching to the Menthol Tobacco Heating System 2.2 for 3 Months (Part 1).减少选定的有害和潜在有害成分的暴露,接近吸烟者改用薄荷醇加热烟草系统 2.2 三个月(第 1 部分)后观察到的戒烟者的暴露水平。
Nicotine Tob Res. 2020 Apr 17;22(4):539-548. doi: 10.1093/ntr/ntz013.
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Effects of Switching to the Tobacco Heating System 2.2 Menthol, Smoking Abstinence, or Continued Cigarette Smoking on Biomarkers of Exposure: A Randomized, Controlled, Open-Label, Multicenter Study in Sequential Confinement and Ambulatory Settings (Part 1).在禁闭和门诊环境中连续进行的一项随机、对照、开放标签、多中心研究(第 1 部分):改用加热不燃烧系统 2.2 薄荷醇、戒烟或继续吸烟对暴露生物标志物的影响。
Nicotine Tob Res. 2018 Jan 5;20(2):161-172. doi: 10.1093/ntr/ntw287.
3
Evaluation of phosphine genotoxicity at occupational levels of exposure in New South Wales, Australia.澳大利亚新南威尔士州职业暴露水平下磷化氢遗传毒性的评估。
Occup Environ Med. 1994 Oct;51(10):700-5. doi: 10.1136/oem.51.10.700.
4
In situ freezing of the rat urinary bladder: DNA adduct formation in the bladder epithelium demonstrated by 32P-postlabeling assay.大鼠膀胱原位冷冻:通过³²P后标记法检测膀胱上皮细胞中的DNA加合物形成。
Jpn J Cancer Res. 1989 Sep;80(9):826-32. doi: 10.1111/j.1349-7006.1989.tb01722.x.

本文引用的文献

1
Inhibition of the mutagenicity of cooked-beef basic fraction by its acidic fraction.熟牛肉碱性组分的酸性组分对其致突变性的抑制作用。
Mutat Res. 1981 Nov;91(6):437-42. doi: 10.1016/0165-7992(81)90049-x.
2
Non-mutagenicity of urine from coffee drinkers compared with that from cigarette smokers.咖啡饮用者尿液与吸烟者尿液的非诱变性比较。
Mutat Res. 1981 Jun;89(2):161-77. doi: 10.1016/0165-1218(81)90122-1.
3
Detection of human exposure to electrophilic compounds by assay of thioether detoxication products in urine.通过检测尿液中的硫醚解毒产物来检测人体对亲电化合物的暴露情况。
Ann Occup Hyg. 1981;24(1):77-92. doi: 10.1093/annhyg/24.1.77.
4
Mutagenicity of extracts of urine from rats treated with aromatic amines.用芳香胺处理的大鼠尿液提取物的致突变性。
Mutat Res. 1980 Oct;79(2):173-6. doi: 10.1016/0165-1218(80)90086-5.
5
Mutagenicity in urine of workers in rubber industry.橡胶行业工人尿液中的致突变性。
Mutat Res. 1980 Sep;79(1):45-52. doi: 10.1016/0165-1218(80)90146-9.
6
Inhibition of the mutagenicity of amino acid pyrolysis products by hemin and other biological pyrrole pigments.血红素及其他生物吡咯色素对氨基酸热解产物致突变性的抑制作用。
Biochem Biophys Res Commun. 1980 Jan 29;92(2):662-8. doi: 10.1016/0006-291x(80)90384-8.
7
Detection of mutagenic activity in human urine following fried pork or bacon meals.
Cancer Lett. 1982 May-Jun;16(1):81-9. doi: 10.1016/0304-3835(82)90094-5.
8
Urinary mutagens in humans after fried pork and bacon meals.
Cancer Lett. 1984 Apr;22(3):275-80. doi: 10.1016/0304-3835(84)90163-0.
9
Urinary mutagen levels in smokers.吸烟者尿液中的诱变剂水平。
Cancer Lett. 1983 Aug;20(1):37-42. doi: 10.1016/0304-3835(83)90184-2.
10
Urinary mutagenicity assays: a problem arising from the presence of histidine associated growth factors in XAD-2 prepared urine concentrates, with particular relevance to assays carried out using the bacterial fluctuation test.
Carcinogenesis. 1983 Nov;4(11):1471-6. doi: 10.1093/carcin/4.11.1471.

尿致突变性作为食物烹饪过程中形成的膳食诱变剂暴露指标。

Urine mutagenicity as an indicator of exposure to dietary mutagens formed during cooking of foods.

作者信息

Baker R S, Darnton-Hill I, Bonin A M, Arlauskas A, Braithwaite C, Wootton M, Truswell A S

出版信息

Environ Health Perspect. 1986 Aug;67:147-52. doi: 10.1289/ehp.8667147.

DOI:10.1289/ehp.8667147
PMID:3757951
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1474409/
Abstract

Studies were undertaken with individuals fed fried bacon meals to determine whether fruit or vegetables, ingested along with bacon, modified uptake and subsequent excretion of bacon mutagen(s). Urinary mutagenic activity was significant in those who had consumed bacon or mixed bacon/vegetable or bacon/fruit meals within the previous 2 to 3 hr period. Although urine activity varied by a factor of 4 among 15 subjects who consumed different meals, there was no evidence from this investigation that fruit or vegetables contributed to the inherent variability in total urinary mutagenic activity. However, some differences in excretion kinetics may be attributable to vegetable or fruit supplements in mixed meals.

摘要

对食用煎培根餐的个体进行了研究,以确定与培根一起摄入的水果或蔬菜是否会改变培根诱变剂的吸收及随后的排泄。在过去2至3小时内食用了培根、培根/蔬菜混合餐或培根/水果混合餐的人的尿液诱变活性显著。尽管在15名食用不同餐食的受试者中,尿液活性相差4倍,但这项调查没有证据表明水果或蔬菜会导致总尿液诱变活性的固有变异性。然而,排泄动力学的一些差异可能归因于混合餐中的蔬菜或水果补充剂。