Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Clinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Early Hum Dev. 2023 Sep;184:105834. doi: 10.1016/j.earlhumdev.2023.105834. Epub 2023 Jul 27.
This retrospective cohort study aimed to evaluate neurodevelopmental outcomes of preterm infants (≤ 34 weeks gestational age) in the NICU.
This retrospective cohort study included 89 preterm infants admitted to the NICU of Ghaem hospital, Mashhad, between 2016 and 2020. Data on neonatal and maternal factors were collected. By recalling the mentioned infants in 2021, the neurodevelopmental outcomes were assessed using the Bayley Scales of Infant and Toddler Development. Data analysis included descriptive statistics, non-parametric tests, and binary logistic regression conducted with SPSS V.26 and R program software.
The sample comprised 48.3 % males with a mean gestational age of 32.10 weeks. Bayley Scale analysis revealed significant associations of Intrauterine Growth Restriction, Pneumothorax, and Bronchopulmonary Dysplasia with impairments in all domains. Diabetes in Pregnancy, Surfactant use, and Necrotizing Enterocolitis were also significantly linked to various impairments. Lower Apgar scores, gestational age, birth weight, and extended hospitalization and oxygen therapy durations correlated with several domain impairments. Logistic regression showed hospitalization duration impacted the coarse motor domain (OR = 0.92, p = 0.019), oxygen therapy duration influenced cognitive, perceptual, and fine motor domains.
This study underscores the importance of considering neonatal and maternal factors when assessing developmental outcomes in preterm infant. Long hospital stays and increase duration of oxygen therapy associated with negative developmental outcomes in different domains of Bayley scales. Early identification of these risk factors and targeted interventions may improve long-term outcomes for preterm children.
本回顾性队列研究旨在评估新生儿重症监护病房（NICU）中早产儿（≤34 周胎龄）的神经发育结局。
本回顾性队列研究纳入了 2016 年至 2020 年期间在马什哈德盖姆医院 NICU 住院的 89 名早产儿。收集了新生儿和产妇因素的数据。通过在 2021 年召回这些婴儿，使用贝利婴幼儿发育量表评估神经发育结局。数据分析包括描述性统计、非参数检验和使用 SPSS V.26 和 R 程序软件进行的二元逻辑回归。
该样本中男性占 48.3%，平均胎龄为 32.10 周。贝利量表分析显示，宫内生长受限、气胸和支气管肺发育不良与所有领域的损伤显著相关。妊娠糖尿病、表面活性剂使用和坏死性小肠结肠炎也与各种损伤显著相关。较低的 Apgar 评分、胎龄、出生体重以及延长的住院时间和吸氧时间与多个领域的损伤相关。逻辑回归显示，住院时间影响粗大运动领域（OR=0.92，p=0.019），吸氧时间影响认知、感知和精细运动领域。
本研究强调了在评估早产儿发育结局时考虑新生儿和产妇因素的重要性。较长的住院时间和增加吸氧时间与贝利量表不同领域的不良发育结局相关。早期识别这些风险因素并采取针对性干预措施可能会改善早产儿的长期结局。
