Becker G D, Parell G J
Ann Otol Rhinol Laryngol. 1979 Mar-Apr;88(2 Pt 1):183-6. doi: 10.1177/000348947908800206.
This study evaluated the prophylactic use of cefazolin in reducing the incidence of infection in patients undetgoing cancer surgery where the upper aerodigestive tract was entered from the neck. A prospective, randomized, double-blind design was conducted in a single hospital. The patient was given placebo or cefazolin, 1 gm intramuscularly with the preoperative medications, then 0.5 gm every six hours for four doses. Of 55 determinate patients, 32 received antibiotics and 23 placebo. Infection rate was 38% (12/32) and 87% (20/23) respectively, representing a statistically significant reduction in infection (P less than 0.001/. There were 30 wound and two nonwound (sinusitis and pneumonia) infections. In conclusion, the perioperative use of cefazolin in patients undergoing cancer surgery where the oral cavity or pharynx has been entered from the neck is useful in reducing the incidence of wound infection.
本研究评估了头孢唑林预防性用药对减少经颈部进入上消化道的癌症手术患者感染发生率的效果。在一家医院采用前瞻性、随机、双盲设计进行研究。患者在术前用药时接受安慰剂或头孢唑林，1克肌肉注射，然后每6小时0.5克，共给药4次。在55例确诊患者中，32例接受抗生素治疗，23例接受安慰剂治疗。感染率分别为38%（12/32）和87%（20/23），表明感染率有统计学意义的降低（P<0.001）。有30例伤口感染和2例非伤口感染（鼻窦炎和肺炎）。总之，对于经颈部进入口腔或咽部的癌症手术患者，围手术期使用头孢唑林有助于降低伤口感染发生率。
