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Abatacept for the prevention of graft versus host disease in pediatric patients receiving 7/8 HLA-mismatched unrelated transplant for hematologic malignancies: a real-world analysis.

作者信息

Raghunandan Sharmila, Gorfinkel Lev, Bratrude Brandi, Suessmuth Yvonne, Hebert Kyle, Neuberg Donna, Williams Kirsten M, Schoettler Michelle L, Langston Amelia A, Kean Leslie S, Qayed Muna, Horan John, Watkins Benjamin K

机构信息

Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, and Emory University, Atlanta, GA, USA.

Dana-Farber Cancer Institute, Boston, MA, USA.

出版信息

Bone Marrow Transplant. 2023 Nov;58(11):1260-1263. doi: 10.1038/s41409-023-02034-z. Epub 2023 Aug 14.

DOI:10.1038/s41409-023-02034-z
PMID:37580396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10622310/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/552a/10622310/d61c8e62eaaa/41409_2023_2034_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/552a/10622310/d61c8e62eaaa/41409_2023_2034_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/552a/10622310/d61c8e62eaaa/41409_2023_2034_Fig1_HTML.jpg

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Abatacept for the prevention of graft versus host disease in pediatric patients receiving 7/8 HLA-mismatched unrelated transplant for hematologic malignancies: a real-world analysis.阿巴西普预防接受7/8 HLA错配非亲缘造血恶性肿瘤移植的儿科患者移植物抗宿主病：一项真实世界分析
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2
Abatacept for graft versus host disease prophylaxis in patients 60 years and older receiving mismatched unrelated donor transplantation for hematologic malignancies.阿巴西普用于预防60岁及以上接受错配无关供体移植治疗血液系统恶性肿瘤患者的移植物抗宿主病。
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Recent developments in HLA-haploidentical transplantations.人类白细胞抗原单倍型相合移植的最新进展
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Are alternative donors really still "alternative?".替代供体真的仍然是“替代的”吗？
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Results of a 2-arm, phase 2 clinical trial using post-transplantation cyclophosphamide for the prevention of graft-versus-host disease in haploidentical donor and mismatched unrelated donor hematopoietic stem cell transplantation.一项双臂2期临床试验的结果，该试验使用移植后环磷酰胺预防单倍体相合供者和错配无关供者造血干细胞移植中的移植物抗宿主病。
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本文引用的文献

1
Abatacept for GVHD prophylaxis can reduce racial disparities by abrogating the impact of mismatching in unrelated donor stem cell transplantation.用于预防移植物抗宿主病的阿巴西普可通过消除无关供体干细胞移植中配型不相合的影响来减少种族差异。
Blood Adv. 2022 Feb 8;6(3):746-749. doi: 10.1182/bloodadvances.2021005208.
2
Phase II Trial of Costimulation Blockade With Abatacept for Prevention of Acute GVHD.阿巴西普阻断共刺激用于预防急性移植物抗宿主病的 II 期临床试验。
J Clin Oncol. 2021 Jun 10;39(17):1865-1877. doi: 10.1200/JCO.20.01086. Epub 2021 Jan 15.
3
Interpretation and Impact of Real-World Clinical Data for the Practicing Clinician.
真实世界临床数据对临床医生的解读和影响。
Adv Ther. 2018 Nov;35(11):1763-1774. doi: 10.1007/s12325-018-0805-y. Epub 2018 Oct 24.
4
Influence of Age on Acute and Chronic GVHD in Children Undergoing HLA-Identical Sibling Bone Marrow Transplantation for Acute Leukemia: Implications for Prophylaxis.年龄对急性白血病行 HLA 相合同胞骨髓移植后急、慢性移植物抗宿主病的影响：对预防措施的启示。
Biol Blood Marrow Transplant. 2018 Mar;24(3):521-528. doi: 10.1016/j.bbmt.2017.11.004. Epub 2017 Nov 16.
5
Real-World Evidence - What Is It and What Can It Tell Us?真实世界证据——它是什么以及能告诉我们什么？
N Engl J Med. 2016 Dec 8;375(23):2293-2297. doi: 10.1056/NEJMsb1609216.
6
HLA match likelihoods for hematopoietic stem-cell grafts in the U.S. registry.美国注册中心造血干细胞移植供者 HLA 配型概率。
N Engl J Med. 2014 Jul 24;371(4):339-48. doi: 10.1056/NEJMsa1311707.
7
Risk factors for acute GVHD and survival after hematopoietic cell transplantation.造血细胞移植后急性移植物抗宿主病的危险因素和生存情况。
Blood. 2012 Jan 5;119(1):296-307. doi: 10.1182/blood-2011-06-364265. Epub 2011 Oct 18.
8
HLA-C antigen mismatch is associated with worse outcome in unrelated donor peripheral blood stem cell transplantation.HLA-C 抗原错配与无关供体外周血造血干细胞移植后不良结局相关。
Biol Blood Marrow Transplant. 2011 Jun;17(6):885-92. doi: 10.1016/j.bbmt.2010.09.012. Epub 2010 Sep 24.
9
Outcomes of pediatric bone marrow transplantation for leukemia and myelodysplasia using matched sibling, mismatched related, or matched unrelated donors.采用匹配同胞供者、非亲缘相关供者或匹配无关供者进行小儿骨髓移植治疗白血病和骨髓增生异常综合征的结果。
Blood. 2010 Nov 11;116(19):4007-15. doi: 10.1182/blood-2010-01-261958. Epub 2010 Jul 29.
10
High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation.高分辨率的供受者人类白细胞抗原（HLA）配型有助于无关供者骨髓移植的成功。
Blood. 2007 Dec 15;110(13):4576-83. doi: 10.1182/blood-2007-06-097386. Epub 2007 Sep 4.