Institute of Sport Sciences, Department of Biomedical Basis of Physical Activity, Academy of Physical Education in Katowice, Katowice, 40-065, Poland.
Institute of Physiotherapy and Health Sciences, Department of Physiotherapy in Internal Diseases, Academy of Physical Education in Katowice, Katowice, 40-065, Poland.
BMC Geriatr. 2023 Aug 14;23(1):489. doi: 10.1186/s12877-023-04205-5.
Given a lack of studies precisely indicating how many steps elderly people should take daily for their antioxidant defence, bone metabolism, and cognitive abilities to improve, our study set out to compare the selected antioxidant, prooxidant, bone turnover, and BDNF indicators between elderly women differing in physical activity (PA) measured by the daily number of steps.
The PA levels of 62 women aged 72.1 ± 5.4 years were assessed based on their daily number of steps and then were used to allocate the participants to three groups: group I (n = 18; <5,000 steps a day); group II (n = 22; from 5,000 to 9,999 steps a day); and group III (n = 22; ≥10,000 steps a day). Blood samples were collected from the participants in early morning hours and subjected to biochemical analysis for prooxidant-antioxidant balance indicators (SOD, CAT, GPx, GR, GSH, UA, MDA and TOS/TOC), bone metabolism indicators (Ca, 25-OH vitamin D, osteocalcin, CTX-I, and PTH), and BDNF levels.
The groups were not statistically significantly different in the activity of SOD, CAT, GPx, and GR, but their concentrations of GSH (H = 22.10, p < 0.001) and UA (H = 12.20, p = 0.002) proved to be significantly associated with the groups' daily PA. The between-group differences in the concentrations of MDA and TOS/TOC were not significant, with both these indicators tending to take higher values in group I than in groups II and III. Significant differences between the groups were established for the concentrations of 25-OH vitamin D (H = 24.21, p < 0.001), osteocalcin (H = 7.88, p = 0.019), CTX-I (H = 12.91, p = 0.002), and BDNF (H = 14.47, p = 0.001), but not for Ca and PTH.
Significantly higher concentrations of GSH, slightly lower oxidative stress indicators, significantly higher BDNF levels, and moderately better bone turnover indicators and resorption markers in the group taking more than 5,000 steps a day suggest that this level of PA can promote successful aging. More research is, however, needed to confirm this finding.
鉴于目前尚缺乏研究明确指出老年人每天需要走多少步才能提高其抗氧化防御能力、促进骨代谢和改善认知能力，我们的研究旨在比较通过每日步数测量的身体活动（PA）水平不同的老年女性的选定抗氧化剂、促氧化剂、骨转换和 BDNF 指标。
62 名年龄为 72.1±5.4 岁的女性的 PA 水平根据其每日步数进行评估，然后将参与者分为三组：组 I（n=18；每天<5000 步）；组 II（n=22；每天 5000-9999 步）；组 III（n=22；每天≥10000 步）。清晨从参与者采集血样，并进行生化分析以检测促氧化剂-抗氧化剂平衡指标（SOD、CAT、GPx、GR、GSH、UA、MDA 和 TOS/TOC）、骨代谢指标（Ca、25-OH 维生素 D、骨钙素、CTX-I 和 PTH）和 BDNF 水平。
各组 SOD、CAT、GPx 和 GR 的活性无统计学差异，但 GSH（H=22.10，p<0.001）和 UA（H=12.20，p=0.002）的浓度与各组的每日 PA 显著相关。组间 MDA 和 TOS/TOC 浓度无显著差异，这两个指标在组 I 中的值均高于组 II 和组 III。25-OH 维生素 D（H=24.21，p<0.001）、骨钙素（H=7.88，p=0.019）、CTX-I（H=12.91，p=0.002）和 BDNF（H=14.47，p=0.001）浓度在组间存在显著差异，但 Ca 和 PTH 浓度无差异。
每天走 5000 步以上的组 GSH 浓度明显升高，氧化应激指标略低，BDNF 水平明显升高，骨转换和吸收标志物适度改善，这表明这种 PA 水平可以促进成功老龄化。然而，需要进一步的研究来证实这一发现。
