Mansur Rodrigo B, Santos Camila M, Rizzo Lucas B, Cunha Graccielle R, Asevedo Elson, Noto Mariane N, Pedrini Mariana, Zeni Maiara, Cordeiro Quirino, McIntyre Roger S, Brietzke Elisa
Research Group in Behavioral Neuroscience of Bipolar Disorder (GP-TB), Department of Psychiatry, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
Mood Disorders Psychopharmacology Unit (MDPU), University Health Network, University of Toronto, Toronto, Canada.
Bipolar Disord. 2016 Aug;18(5):433-9. doi: 10.1111/bdi.12418. Epub 2016 Aug 4.
Accumulating evidence indicates that oxidative stress and neurotrophins have a bidirectional relationship. In this post hoc, exploratory analysis, we investigated the association between plasma brain-derived neurotrophic factor (BDNF) levels and activities of the antioxidant enzymes glutathione peroxidase (GPx) and superoxide dismutase (SOD) in individuals with bipolar disorder (BD) and healthy controls.
We measured plasma levels of BDNF and activities of GPx and SOD in individuals with BD (n=59) and healthy controls (n=26). Information related to current and past psychiatric/medical history, as well as to metabolic comorbidities, was also reported.
There were negative correlations between BDNF, GPx (r=-.449, P≤.001) and GPx/SOD ratio (r=-.503, P<.001), and a positive correlation between BDNF and SOD (r=.254, P=.020). There was a moderating effect of body mass index (BMI) on the association between BDNF and GPx/SOD rate ratio [(RR)=1.002, P=.034]; interactions between impaired glucose metabolism (IGM), GPx (RR=1.016, P=.033), and GPx/SOD ratio (RR=1.026, P=.002) were also observed. These results were significant in models that included age, gender, alcohol, tobacco and medication use.
There was a robust and independent correlation between peripheral BDNF and antioxidant enzyme activities in individuals with BD, which was moderated by metabolic comorbidities. These results reinforce the concept that these systems are associated and further extend knowledge of the putative effect of metabolic comorbidities in the pathophysiological substrates of BD.
越来越多的证据表明氧化应激与神经营养因子之间存在双向关系。在这项事后探索性分析中，我们研究了双相情感障碍（BD）患者和健康对照者血浆脑源性神经营养因子（BDNF）水平与抗氧化酶谷胱甘肽过氧化物酶（GPx）和超氧化物歧化酶（SOD）活性之间的关联。
我们测量了BD患者（n = 59）和健康对照者（n = 26）的血浆BDNF水平以及GPx和SOD的活性。还报告了与当前和过去的精神/病史以及代谢合并症相关的信息。
BDNF与GPx（r = -0.449，P≤0.001）和GPx/SOD比值（r = -0.503，P<0.001）之间存在负相关，BDNF与SOD之间存在正相关（r = 0.254，P = 0.020）。体重指数（BMI）对BDNF与GPx/SOD率比之间的关联具有调节作用[（RR）= 1.002，P = 0.034]；还观察到葡萄糖代谢受损（IGM）、GPx（RR = 1.016，P = 0.033）和GPx/SOD比值（RR = 1.026，P = 0.002）之间的相互作用。这些结果在包括年龄、性别、酒精、烟草和药物使用的模型中具有显著性。
BD患者外周BDNF与抗氧化酶活性之间存在强烈且独立的相关性，代谢合并症对其具有调节作用。这些结果强化了这些系统相关的概念，并进一步扩展了关于代谢合并症在BD病理生理底物中假定作用的认识。
