Mood Disorders Unit, Faculty of Medicine FMUSP, University of Sao Paulo, BR Ovideo Pires de Campos St., São Paulo, SP, 785 05403-010, Brazil.
Independent Consultant, Brasilia, Brazil.
Health Qual Life Outcomes. 2023 Aug 14;21(1):88. doi: 10.1186/s12955-023-02178-y.
Distorted thoughts are common in Major Depressive Disorder (MDD), and can impact patients' perceptions of depression severity, and predict chronicity and treatment response. This study aimed to investigate whether distorted thoughts mediate depressive symptoms in MDD over a 6-month period.
These are secondary results from a study that followed 119 patients diagnosed with moderate to severe MDD for 6 months. Diagnoses were confirmed by the Structured Interview for DSM-IV (SCID-CV). The analysis was composed of results from the Hamilton Depression Rating Scale (HAMD-17), the Montgomery-Asberg Depression Rating Scale (MADRS), the second edition of the Beck Depression Inventory (BDI-II), and the Depression Thoughts Scale (DTS) collected at weeks 1, 8, 12 and 24.
Results showed that the DTS mediated the relationship between depressive symptoms experienced approximately 3 months after starting antidepressant treatment.
Cognitive distortions were linked as a mediator to depressive symptoms, highlighting the importance of early psychological interventions in patients with MDD who exhibit these distortions.
NCT02268487.
在重度抑郁症（MDD）中，扭曲的思维很常见，这可能会影响患者对抑郁严重程度的感知，并预测疾病的慢性程度和治疗反应。本研究旨在探讨在 6 个月的时间内，扭曲的思维是否会影响 MDD 患者的抑郁症状。
这是一项对 119 名被诊断为中重度 MDD 的患者进行为期 6 个月随访的研究的次要结果。诊断通过 DSM-IV 结构访谈（SCID-CV）进行确认。分析结果包括在第 1、8、12 和 24 周时收集的汉密尔顿抑郁量表（HAMD-17）、蒙哥马利-阿斯伯格抑郁评定量表（MADRS）、贝克抑郁量表第二版（BDI-II）和抑郁思维量表（DTS）的结果。
结果显示，在开始抗抑郁治疗大约 3 个月后，DTS 介导了抑郁症状之间的关系。
认知扭曲被认为是抑郁症状的中介因素，这突显了在表现出这些扭曲的 MDD 患者中早期进行心理干预的重要性。
NCT02268487。
