Humaira Khan -, Sammiya Uraneb -, Rehana Mushtaq -, Farhat Bano -
University of Health Sciences, Lahore, Pakistan.
Obs & Gynae Department, National Medical College and Teaching Hospital, Parsa, Birgunj, Nepal.
Pak J Pharm Sci. 2023 May;36(3):749-753.
Hypertensive disorders of pregnancy are a serious and life-threatening condition often complicating the pregnancy leading to preeclampsia, eclampsia, maternal and neonatal mortality and morbidity. Preeclampsia is myriad of diseases starting from improper remodeling of spiral arteries, poor placentation leading to fatal consequences of intrauterine fetal and maternal death due to uncontrolled blood pressure. Thirty-three preeclamptic women in Group 1 and thirty-three healthy pregnant in group 2 has been taken in this research. Statistical analysis and evaluation were performed by utilizing SPSS version 23.0. Result of our research show significant decrease in serum apelin and elabela and association of these hormones with parity, body mass index (BMI), C-reactive protein (CRP) , systolic and diastolic blood pressure in preeclamptic women as compared to healthy pregnant while no significant association with age.
妊娠期高血压疾病是一种严重且危及生命的病症，常使妊娠复杂化，导致子痫前期、子痫、孕产妇和新生儿死亡及发病。子痫前期是一系列疾病，始于螺旋动脉重塑不当、胎盘形成不良，由于血压失控导致胎儿宫内死亡和孕产妇死亡等致命后果。本研究纳入了1组的33名单纯子痫前期妇女和2组的33名健康孕妇。使用SPSS 23.0版本进行统计分析和评估。我们的研究结果显示，与健康孕妇相比，子痫前期妇女血清apelin和elabela显著降低，且这些激素与胎次、体重指数（BMI）、C反应蛋白（CRP）、收缩压和舒张压相关，而与年龄无显著关联。
