Department of Obstetrics and Gynecology, Bursa Yüksek İhtisas Education and Research Hospital, Bursa, Turkey.
Department of Obstetrics and Gynecology, Manisa Merkezefendi State Hospital, Merkezefendi, Manisa, Turkey.
J Matern Fetal Neonatal Med. 2022 May;35(10):1848-1852. doi: 10.1080/14767058.2020.1814238. Epub 2020 Sep 1.
The aim of this study was to investigate the serum levels of mild, severe preeclamptic pregnants and normotensive pregnant women to determine whether there is a correlation between preeclampsia and their serum levels.
This prospective case-control study included 48 preeclamptic and 39 healthy normotensive pregnants. The control group was composed of body mass index and age matched pregnant women. Preeclamptic patients were divided into two groups as mild preeclampsia and severe preeclampsia. Serum apelin levels were determined by EnzymeImmunometricAssay (EIA) biochemical test.
Serum apelin levels were found to be significantly lower in the preeclampsia group. It was 0.75 ± 0.24 ng/ml in mild preeclampsia and 0.55 ± 0.18 ng/ml in the severe preeclampsia and 0.91 ± 0.20 ng/ml in the control group. There was a strong inverse correlation between serum apelin levels and Systolic Blood Pressure (SBP) (: -0.429 : 0.002).
In conclusion, the role of apelin and apelinergic system in cardiovascular system and placental development and their place in preeclampsia is still an issue. In preeclampsia, the deterioration of the cardiovascular protective effect of apelin by other enzymes may also contribute to the deterioration of fetal development. More detailed studies are needed.
本研究旨在探讨轻度子痫前期、重度子痫前期孕妇与正常血压孕妇血清中的浓度，以确定子痫前期与血清浓度之间是否存在相关性。
本前瞻性病例对照研究纳入了 48 例子痫前期患者和 39 例健康的正常血压孕妇。对照组由体重指数和年龄匹配的孕妇组成。子痫前期患者分为轻度子痫前期和重度子痫前期两组。采用酶免疫测定法（EIA）生化试验测定血清中apelin 的水平。
子痫前期组血清 apelin 水平显著降低。轻度子痫前期组为 0.75±0.24ng/ml，重度子痫前期组为 0.55±0.18ng/ml，对照组为 0.91±0.20ng/ml。血清 apelin 水平与收缩压（SBP）呈强烈负相关（r=-0.429，P=0.002）。
总之，apelin 及其相关系统在心血管系统和胎盘发育中的作用及其在子痫前期中的地位仍存在争议。在子痫前期中，其他酶对 apelin 心血管保护作用的恶化也可能导致胎儿发育恶化。需要进行更详细的研究。
