Department of Obstetrics and Gynecology, Umraniye Training and Research Hospital, Istanbul, Turkey.
Department of Obstetrics and Gynecology, Maternal Fetal Unit, Umraniye Training and Research Hospital, Istanbul, Turkey.
J Matern Fetal Neonatal Med. 2024 Dec;37(1):2341298. doi: 10.1080/14767058.2024.2341298. Epub 2024 Apr 16.
We aimed to investigate the relationship between preeclampsia and maternal serum apelin-13 and apelin-36 concentrations.
This cross-sectional study was carried out in the Gynecology and Obstetrics Clinic of Umraniye Training and Research Hospital. The preeclampsia group consisted of 40 pregnant women diagnosed with preeclampsia, and the control group consisted of 40 healthy pregnant women matched with the preeclampsia group in terms of age and body mass index. The two groups were compared in terms of maternal serum apelin-13 and apelin-36 concentrations.
Both groups were similar in terms of demographic characteristics and the gestational week at blood sampling. Maternal serum apelin-13 and apelin-36 concentrations were significantly lower in the preeclampsia group than in the control group ( = 0.005, = 0.001, respectively). The optimal cutoff value for the prediction of preeclampsia in receiver operator curve analysis for apelin-13 was determined as 1781.67 pg/ml with 60% sensitivity and 60% specificity, and 885.5 pg/ml for apelin-36 with 67% sensitivity and 65% specificity. We divided the preeclampsia group into two groups mild and severe and compared the three groups in terms of maternal serum apelin-13 and apelin-36 concentrations. The lowest apelin-13 concentration was detected in the severe preeclampsia group, while the lowest apelin-36 concentration was detected in the mild preeclampsia group ( = 0.020, = 0.003, respectively). Considering the onset of the disease, we divided the preeclampsia group into two groups early and late-onset, then compared the three groups in terms of maternal serum apelin-13 and apelin-36 concentrations. The lowest maternal serum apelin-13 and apelin-36 concentrations were detected in the early-onset preeclampsia group ( = 0.016, = 0.001, respectively).
It was determined that serum apelin-13 and apelin-36 concentrations were significantly lower in preeclamptic pregnant women, this decrease was more significant in early-onset preeclampsia, and low maternal serum apelin-13 concentration was more associated with the severity of preeclampsia.
本研究旨在探讨子痫前期与母体血清中apelin-13 和 apelin-36 浓度的关系。
本横断面研究在乌鲁米耶培训与研究医院妇产科进行。子痫前期组由 40 例诊断为子痫前期的孕妇组成，对照组由 40 例年龄和体重指数与子痫前期组相匹配的健康孕妇组成。比较两组孕妇的血清 apelin-13 和 apelin-36 浓度。
两组孕妇的一般特征和采血时的孕周相似。子痫前期组孕妇血清 apelin-13 和 apelin-36 浓度明显低于对照组（=0.005，=0.001）。受试者工作特征曲线分析显示，apelin-13 预测子痫前期的最佳截断值为 1781.67pg/ml，灵敏度为 60%，特异性为 60%，apelin-36 的最佳截断值为 885.5pg/ml，灵敏度为 67%，特异性为 65%。我们将子痫前期组分为轻度和重度两组，并比较三组孕妇的血清 apelin-13 和 apelin-36 浓度。在重度子痫前期组中检测到最低的 apelin-13 浓度，而在轻度子痫前期组中检测到最低的 apelin-36 浓度（=0.020，=0.003）。考虑疾病的发病时间，我们将子痫前期组分为早发型和晚发型两组，然后比较三组孕妇的血清 apelin-13 和 apelin-36 浓度。在早发型子痫前期组中检测到最低的血清 apelin-13 和 apelin-36 浓度（=0.016，=0.001）。
确定子痫前期孕妇血清 apelin-13 和 apelin-36 浓度明显降低，早发型子痫前期降低更明显，且母体血清 apelin-13 浓度降低与子痫前期严重程度更相关。
