Zwas S T, Samra D, Samra Y, Sibber G R
Eur J Nucl Med. 1986;12(3):125-9. doi: 10.1007/BF00276704.
Twenty-three subjects who had a splenectomy as a result of trauma underwent scintigraphic evaluation with a sensitive heat-denatured 99mTc-labeled red blood cells (DRBC). This method enabled detection of ectopic splenic tissue foci (ESTF) as small as 1 X 1 cm in diameter. ESTF splenosis or accessory spleen was detected in 15 cases (65%), a higher incidence than previously reported. The size of the ESTF ranged from 1 X 1 to 5 X 10 cm (0.8-40 cm2), and 53% were less than 2 X 2 cma (3 cm2). A new multiparametric scintigraphic evaluating technique is described, which estimates the quantity of ESTF and its grade of activity, relative to that of the liver. The technique is a highly efficient assessor of ESTF function. Good correlation was found between the size and activity of the ESTF and the presence of Howell-Jolly bodies (HJB), but with a low sensitivity for detecting small ESTF. Correlation was low between residual splenic tissue and concentrations of IgM, IgA and IgG immunoglobulins. The 99mTc-DRBC method described is recommended for verification of ESTF existence, localization, and function.
23名因外伤行脾切除术的患者接受了用热变性的99mTc标记红细胞（DRBC）进行的闪烁扫描评估。该方法能够检测到直径小至1×1厘米的异位脾组织灶（ESTF）。在15例（65%）患者中检测到了脾组织植入或副脾，其发生率高于先前报道。ESTF的大小范围为1×1至5×10厘米（0.8 - 40平方厘米），53%小于2×2厘米（3平方厘米）。本文描述了一种新的多参数闪烁扫描评估技术，该技术可估计ESTF的数量及其相对于肝脏的活性等级。该技术是ESTF功能的高效评估方法。ESTF的大小和活性与豪-乔小体（HJB）的存在之间存在良好的相关性，但对检测小ESTF的敏感性较低。残余脾组织与IgM、IgA和IgG免疫球蛋白浓度之间的相关性较低。推荐使用本文所述的99mTc - DRBC方法来验证ESTF的存在、定位和功能。
