Yanagi Y, Hirose S, Nagasawa R, Shirai T, Mak T W, Tada T
Eur J Immunol. 1986 Sep;16(9):1179-82. doi: 10.1002/eji.1830160925.
To determine the transacting genetic factors of NZW contributing to the development of autoimmune disease in (NZB X NZW)F1 (B/W F1) mice, we examined the relationship between the T cell receptor beta chain gene deletion and the severity of autoimmune manifestations in 76 B/W F1 X NZB backcross mice. Very high association between the T cell receptor beta chain gene deletion and the development of autoimmune manifestations including the production of IgG anti-DNA antibodies and circulating retroviral gp70 immune complexes was observed, indicating that a defect in the NZW T cell receptor beta chain gene or a locus closely linked to it contributes to the autoantibody formation in B/W F1.
为了确定新西兰白兔（NZW）中导致（新西兰黑兔×新西兰白兔）F1（B/W F1）小鼠自身免疫性疾病发展的相互作用遗传因素，我们研究了76只B/W F1×新西兰黑兔回交小鼠中T细胞受体β链基因缺失与自身免疫表现严重程度之间的关系。观察到T细胞受体β链基因缺失与自身免疫表现的发展之间存在非常高的关联性，包括IgG抗DNA抗体的产生和循环逆转录病毒gp70免疫复合物，这表明NZW T细胞受体β链基因的缺陷或与其紧密连锁的基因座促成了B/W F1中的自身抗体形成。
