Laboratory of Cell Signal Transduction, School of Basic Medical Sciences, Henan University, Kaifeng 475001, China.
State Key Laboratory of Crop Stress Adaptation and Improvement, State Key Laboratory of Cotton Biology, School of Life Sciences, Henan University, Kaifeng 475001, China.
J Exp Bot. 2023 Nov 21;74(21):6431-6447. doi: 10.1093/jxb/erad323.
Pseudouridine is one of the well-known chemical modifications in various RNA species. Current advances to detect pseudouridine show that the pseudouridine landscape is dynamic and affects multiple cellular processes. Although our understanding of this post-transcriptional modification mainly depends on yeast and human models, the recent findings provide strong evidence for the critical role of pseudouridine in plants. Here, we review the current knowledge of pseudouridine in plant RNAs, including its synthesis, degradation, regulatory mechanisms, and functions. Moreover, we propose future areas of research on pseudouridine modification in plants.
假尿嘧啶核苷是各种 RNA 分子中一种众所周知的化学修饰。目前对假尿嘧啶核苷的检测进展表明，假尿嘧啶核苷的分布是动态的，并影响多种细胞过程。尽管我们对这种转录后修饰的认识主要依赖于酵母和人类模型，但最近的发现为假尿嘧啶核苷在植物中的关键作用提供了有力证据。在这里，我们综述了植物 RNA 中假尿嘧啶核苷的最新知识，包括其合成、降解、调控机制和功能。此外，我们还提出了植物中假尿嘧啶核苷修饰的未来研究领域。
