Programa de Pós-Graduação em Medicina Translacional, Departamento de Medicina, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
Departamento de Dermatologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Rua dos Otonis, 861 - Vila Clementino, São Paulo, 04025-002, Brazil.
Sleep Breath. 2024 Mar;28(1):561-563. doi: 10.1007/s11325-023-02898-x. Epub 2023 Aug 15.
Sleep disruption, especially that resulting from obstructive sleep apnea (OSA) - a widely prevalent sleep disorder - can lead to important systemic repercussions. We raise a subject of current interest, namely the possible relationship between sleep in general, OSA, and irritable bowel syndrome (IBS), an intestinal disease that can be made worse by stressful events. The intermittent hypoxia caused by OSA can induce alterations in the gut microbiota, which can lead to the dysregulation of the gut-brain axis and the worsening of IBS. This may be considered to be a circular relationship, with OSA playing a crucial role in the worsening of bowel symptoms, which in turn have a negative effect on sleep. Thus, based on previous evidence, we suggest that improving sleep quality could be a key to disrupting this relationship of IBS aggravation and OSA.
睡眠紊乱，特别是由阻塞性睡眠呼吸暂停（OSA）引起的睡眠紊乱（一种广泛存在的睡眠障碍），可能会导致重要的全身性影响。我们提出了一个当前关注的话题，即一般睡眠、OSA 和肠易激综合征（IBS）之间可能存在的关系，IBS 是一种可因应激事件而加重的肠道疾病。OSA 引起的间歇性缺氧会引起肠道微生物群的改变，从而导致肠道-大脑轴的失调和 IBS 的恶化。这可以被认为是一个循环关系，OSA 在肠道症状恶化中起着关键作用，而肠道症状的恶化反过来又对睡眠产生负面影响。因此，根据以往的证据，我们认为改善睡眠质量可能是打破这种 IBS 恶化和 OSA 关系的关键。
