Department of Radiology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
Department of Psychology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
PLoS One. 2023 Aug 15;18(8):e0289735. doi: 10.1371/journal.pone.0289735. eCollection 2023.
Researchers find it difficult to distinguish between depression with ASD (Depress-wASD) and without ASD (Depression) in adult patients. We aimed to clarify the differences in brain connectivity between patients with depression with ASD and without ASD.
From April 2017 to February 2019, 22 patients with suspected depression were admitted to the hospital for diagnosis or follow-up and met the inclusion criteria. The diagnosis was determined according to the Diagnostic and Statistical Manual of Mental Disorders-5 by skilled psychiatrists. The Hamilton Depression Rating Scale (HAM-D), Young Mania Raging Scale (YMRS), Mini-International Neuropsychiatric Interview, Parent-interview ASD Rating Scale-Text Revision (PARS-TR), and Autism-Spectrum Quotient-Japanese version (AQ-J) were used to assess the patients' background and help with diagnosis. Resting-state functional magnetic resonance imaging (rs-fMRI) was performed using the 3-T-MRI system. rs-fMRI was processed using the CONN functional connectivity toolbox. Voxel-based morphometry was performed using structural images.
No significant difference was observed between the Depress-wASD and Depression groups using the HAM-D, YMRS, AQ-J, Intelligence Quotient (IQ), and verbal IQ results. rs-fMRI for the Depress-wASD group indicated a positive connection between the salience network (SN) and right supramarginal gyrus (SMG) and a negative connection between the SN and hippocampus and para-hippocampus than that for the Depression group. No significant structural differences were observed between the groups.
We identified differences in the SN involving the SMG and hippocampal regions between the Depress-wASD and Depression groups.
研究人员发现，很难区分成人患者的伴自闭症谱系障碍的抑郁症（Depress-wASD）和不伴自闭症谱系障碍的抑郁症（Depression）。我们旨在阐明伴自闭症谱系障碍的抑郁症患者和不伴自闭症谱系障碍的抑郁症患者之间大脑连接的差异。
从 2017 年 4 月到 2019 年 2 月，22 名疑似抑郁症的患者因诊断或随访而入院，并符合纳入标准。诊断由熟练的精神科医生根据《精神障碍诊断与统计手册-5》确定。采用汉密尔顿抑郁评定量表（HAM-D）、杨氏躁狂评定量表（YMRS）、迷你国际神经精神访谈、父母访谈自闭症评定量表-文本修订版（PARS-TR）和自闭症-谱系商数-日本版（AQ-J）评估患者的背景并协助诊断。使用 3-T-MRI 系统进行静息态功能磁共振成像（rs-fMRI）。使用 CONN 功能连接工具包处理 rs-fMRI。使用结构图像进行基于体素的形态计量学。
使用 HAM-D、YMRS、AQ-J、智商和言语智商结果，未观察到 Depress-wASD 组和 Depression 组之间有显著差异。Depress-wASD 组的 rs-fMRI 显示，与 Depression 组相比，突显网络（SN）与右侧缘上回（SMG）之间存在正连接，而 SN 与海马体和海马旁回之间存在负连接。两组之间未观察到显著的结构差异。
我们确定了 Depress-wASD 组和 Depression 组之间涉及 SMG 和海马区域的 SN 差异。
