Department of General Surgery (Hepatobiliary Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China.
Eur J Med Res. 2023 Aug 16;28(1):283. doi: 10.1186/s40001-023-01252-x.
The existing literature on the combination of acute pancreatitis (AP) and COVID-19 is scarce. The objective of our study is to compare the clinical outcomes and occurrence of long COVID syndrome in AP patients with and without COVID-19, while investigating the potential impact of COVID-19 on the severity, mortality rate, and long COVID syndrome in these patients.
This retrospective, observational study was conducted at a single center. It included patients aged 18 years and above who were diagnosed with AP during the pandemic. Patients were categorized into two groups based on the results of RT-qPCR testing: the SARS-CoV-2-positive group and the SARS-CoV-2-negative group. The study aimed to compare the severity of AP, mortality rate, and occurrence of long COVID syndrome between these two groups.
A retrospective review was conducted on 122 patients diagnosed with acute pancreatitis between December 1, 2022, and January 31, 2023. Out of these patients, 100 were included in the study. The analysis revealed no significant differences in mortality rate, severity, and sequelae between AP patients with COVID-19 and those without COVID-19 (p > 0.005). However, a statistically significant difference was observed in the occurrence of long COVID syndrome, specifically in the presence of cough (p = 0.04).
This study demonstrates that the presence of COVID-19 in patients with pancreatitis does not lead to an increase in the mortality and severity rate of pancreatitis.
关于急性胰腺炎（AP）合并 COVID-19 的现有文献很少。我们的研究目的是比较伴有和不伴有 COVID-19 的 AP 患者的临床结局和长新冠综合征的发生情况，并探讨 COVID-19 对这些患者严重程度、死亡率和长新冠综合征的潜在影响。
这是一项在单一中心进行的回顾性观察研究。纳入了在大流行期间被诊断为 AP 的年龄在 18 岁及以上的患者。根据 RT-qPCR 检测结果，将患者分为 SARS-CoV-2 阳性组和 SARS-CoV-2 阴性组。本研究旨在比较两组患者的 AP 严重程度、死亡率和长新冠综合征的发生情况。
对 2022 年 12 月 1 日至 2023 年 1 月 31 日期间被诊断为急性胰腺炎的 122 例患者进行了回顾性审查。其中 100 例患者纳入研究。分析结果显示，COVID-19 阳性和 COVID-19 阴性的 AP 患者的死亡率、严重程度和后遗症无显著差异（p>0.005）。然而，在长新冠综合征的发生方面，尤其是咳嗽的存在方面，观察到了具有统计学意义的差异（p=0.04）。
本研究表明，胰腺炎患者中 COVID-19 的存在不会导致胰腺炎的死亡率和严重程度增加。
