Seĭfulla R D, Vaĭsberg M A, Syrov V N
Farmakol Toksikol. 1986 Jul-Aug;49(4):40-2.
Oral ratibol (10 mg/kg) produced in rabbits a decrease of blood coagulability (increased the time of thromboelastogram reaction, reduced the activity of prothrombin complex according to Quick, tolerance to heparin and activity of factors II, VII, XIII and concentration of factor I). The drug administration (1 mg/kg) for 20 days caused at the first stage a decrease and at the second stage an increase of blood coagulability. At a single and 20-day administration ratibol enhanced the fibrinolytic activity, reduced the resistance of fibrin clot to streptokinase and increased the antithrombin activity.
口服雷替波尔（10毫克/千克）可使家兔血液凝固性降低（血栓弹力图反应时间延长，根据奎克法测定的凝血酶原复合物活性降低，对肝素的耐受性以及因子II、VII、XIII的活性和因子I的浓度降低）。给药20天（1毫克/千克），第一阶段会导致血液凝固性降低，第二阶段则会使其升高。单次给药及连续给药20天，雷替波尔均可增强纤溶活性，降低纤维蛋白凝块对链激酶的抵抗力，并提高抗凝血酶活性。
