[鼠李醇、去氢表雄酮和茄解定对血液凝固系统的影响]
[The effect of ratibol, retabolil and solasodin on the blood coagulation system].
作者信息
Seĭfulla R D, Vaĭsberg M A, Sokolov S Ia, Kim E K, Baĭramkulov Kh D
出版信息
Biull Eksp Biol Med. 1987 Apr;103(4):427-30.
It has been established that ratibol, retabolil and solasodin in doses 5 and 10 mg/kg proved to have a slight anticoagulative effect. The same effect has been observed during 20 days of oral retabolil and solasodin intake. Ratibol was characterized by a two-step action. All three steroids activated factors II, VII, XIII and diminished factor I concentration. These changes were accomplished with the fall of antithrombin activity and decrease in resistance to streptokinase. The fibrinolysis level has been raised under the effect of the steroids studied.
已经确定，剂量为5毫克/千克和10毫克/千克的去氢表雄酮、羟甲雄酮和茄解定具有轻微的抗凝血作用。在口服羟甲雄酮和茄解定20天期间也观察到了同样的效果。去氢表雄酮具有两步作用。所有三种类固醇都激活了凝血因子II、VII、XIII，并降低了凝血因子I的浓度。这些变化伴随着抗凝血酶活性的下降和对链激酶抗性的降低。在所研究的类固醇的作用下，纤维蛋白溶解水平有所提高。
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