Vysotskiĭ I B
Antibiotiki. 1984 Aug;29(8):590-4.
The seasonal characteristic features of the efficacy of antioxidants in tetracycline affections of the liver were revealed in the experiments with 182 noninbred albino male rats. It was shown that sodium selenite had the most pronounced hepatoprotective effect in autumn and winter, while vitamin E was most effective in spring and summer. The combination of sodium selenite with vitamin E recovered impaired bile excretion in autumn, spring and summer. In winter, the recovery was less effective. It is concluded that the time factor plays a significant role in tetracycline hepatotoxicity and efficacy of antioxidants in tetracycline affections of the liver.
在对182只非近交系雄性白化大鼠进行的实验中，揭示了抗氧化剂对四环素所致肝脏病变疗效的季节性特征。结果表明，亚硒酸钠在秋冬季节具有最显著的肝保护作用，而维生素E在春夏季节最为有效。亚硒酸钠与维生素E联合使用在秋、春、夏三个季节可恢复受损的胆汁排泄。在冬季，恢复效果较差。得出的结论是，时间因素在四环素肝毒性以及抗氧化剂对四环素所致肝脏病变的疗效中起着重要作用。
