[3,12-B-二甲基八氢吲哚-(2,3-a)-喹嗪对实验动物酒精偏好的影响]
[Effect of 3,12-B-dimethyloctahydroindolo-(2,3-a)-quinolyzine on the alcohol predilection of laboratory animals].
作者信息
Borisov M M, Mufazalova T P, Safrazbekian R R, Arzanunts E M, Sukasian R S
出版信息
Farmakol Toksikol. 1986 Jul-Aug;49(4):95-7.
PMID:3758341
Abstract
It was shown that 3,12-b-dimethyl-octahydroindol-(2,3-a) quinolyzine (at the dose of 1/6 of LD50) exerted an antialcohol effect in mice and rats which is probably due to an increased content of the brain 5-hydroxytryptamine resulting from selective inhibition of its deamination.
摘要
结果表明，3,12 - b - 二甲基 - 八氢吲哚 -（2,3 - a）喹嗪（剂量为半数致死量的1/6）对小鼠和大鼠具有抗酒精作用，这可能是由于其对5 - 羟色胺脱氨作用的选择性抑制导致大脑中5 - 羟色胺含量增加所致。
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