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用于三阴性乳腺癌治疗的氧化锌纳米颗粒嵌入石墨相氮化碳的研发

The development of ZnO nanoparticle-embedded graphitic-carbon nitride towards triple-negative breast cancer therapy.

作者信息

Padmanabhan Varun Prasath, Sivashanmugam Pugalmani, S M Mubashera, Sagadevan Suresh, Kulandaivelu Ravichandran

机构信息

Department of Analytical Chemistry, University of Madras Guindy Campus Chennai 600 025 India

Department of Orthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University Chennai India.

出版信息

RSC Adv. 2023 Aug 14;13(35):24333-24342. doi: 10.1039/d3ra02887a. eCollection 2023 Aug 11.

DOI:10.1039/d3ra02887a
PMID:37583658
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10424565/
Abstract

The present study deals with the effects of curcumin-loaded ZnO nanoparticles (NPs) embedded in graphitic-carbon nitride (g-CN) sheets for breast cancer cells. The synthesis of these sheets was carried out by a simple co-precipitation method. The physicochemical and thermal properties of the composite sheets were studied using various characterization techniques. The powder X-ray diffraction and high-resolution transmission electron microscopy analyses confirmed the hexagonal wurtzite phase of the ZnO nanoparticles, which were randomly distributed on the g-CN nanosheets, generating a finely bonded interface between the two components. The X-ray photoelectron spectroscopy analysis confirmed the successful formation of the g-CN@ZnO composite, while the thermal studies revealed the thermal stability of the composite. In addition, the drug release and kinetics studies proved that the release of curcumin was more significant under acidic conditions (pH 5) compared with neutral pH (7.4). Further, the biological assays verified the antibacterial activity (against two different cultures of and ) and anticancer activity (against MDA-MB-231 cancer cells) of the g-CN@ZnO/C nanocomposite. Finally, the lactate dehydrogenase activity assay presented the cytotoxic assessment of the nanocomposite based on its cytoplasmic activity and the extent of enzymes released from the damaged cells.

摘要

本研究探讨了负载姜黄素的氧化锌纳米颗粒（NPs）嵌入石墨相氮化碳（g-CN）片材对乳腺癌细胞的影响。这些片材通过简单的共沉淀法合成。使用各种表征技术研究了复合片材的物理化学和热性能。粉末X射线衍射和高分辨率透射电子显微镜分析证实了氧化锌纳米颗粒的六方纤锌矿相，其随机分布在g-CN纳米片上，在两种组分之间形成了紧密结合的界面。X射线光电子能谱分析证实了g-CN@ZnO复合材料的成功形成，而热学研究揭示了该复合材料的热稳定性。此外，药物释放和动力学研究证明，与中性pH值（7.4）相比，姜黄素在酸性条件（pH 5）下的释放更为显著。此外，生物学试验验证了g-CN@ZnO/C纳米复合材料的抗菌活性（针对两种不同的培养物）和抗癌活性（针对MDA-MB-231癌细胞）。最后，乳酸脱氢酶活性测定基于其细胞质活性和受损细胞释放的酶的程度，对纳米复合材料进行了细胞毒性评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6477/10424565/ffc99cf60fff/d3ra02887a-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6477/10424565/f12ea6c35fca/d3ra02887a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6477/10424565/5e1163041894/d3ra02887a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6477/10424565/5b41b0a0eca5/d3ra02887a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6477/10424565/f736aa4d6a33/d3ra02887a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6477/10424565/ce1b32009993/d3ra02887a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6477/10424565/971b3312d1d1/d3ra02887a-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6477/10424565/0a504e855ee5/d3ra02887a-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6477/10424565/6b685a388a12/d3ra02887a-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6477/10424565/88f8ccb44bea/d3ra02887a-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6477/10424565/ffc99cf60fff/d3ra02887a-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6477/10424565/f12ea6c35fca/d3ra02887a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6477/10424565/5e1163041894/d3ra02887a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6477/10424565/5b41b0a0eca5/d3ra02887a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6477/10424565/f736aa4d6a33/d3ra02887a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6477/10424565/ce1b32009993/d3ra02887a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6477/10424565/971b3312d1d1/d3ra02887a-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6477/10424565/0a504e855ee5/d3ra02887a-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6477/10424565/6b685a388a12/d3ra02887a-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6477/10424565/88f8ccb44bea/d3ra02887a-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6477/10424565/ffc99cf60fff/d3ra02887a-f10.jpg

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