McMahon Kevin R, Gemma Nicholas, Clapp McKenzie, Sanchez-Montejo Patricia, Dibello Joseph, Laipply Erica
Department of General Surgery, Summa Health System, Akron, OH 44304, United States.
World J Clin Oncol. 2023 Jul 24;14(7):259-264. doi: 10.5306/wjco.v14.i7.259.
The incidence of anal cancer has been increasing in the United States. Smoking is a well-established risk factor; however, the impact of smoking on disease re-currence and outcome has not been well studied. The aim of this study was to assess the association between anal cancer recurrence and cigarette smoking.
To investigate the relationship between cigarette smoking status and anal cancer treatment outcome.
The cancer registry from a single, community hospital was screened for patients with anal cancer between 2010 and 2021. The following characteristics were gathered from the database: Age; sex; cigarette smoking history; American Joint Committee on Cancer Clinical Stage Group; response to therapy; recurrence; time to recurrence; mortality; time to death; and length of follow-up. Patients were divided into the following groups: Current smokers; former smokers; and never smokers. SPSSv25.0 software (IBM Corp., Armonk, NY, United States) was used for statistical analysis.
A total of 95 patients from the database met the screening criteria. There were 37 never smokers, 22 former smokers, and 36 current smokers. There was no difference between groups in regards to race or sex. There was no difference in the American Joint Committee on Cancer Clinical Stage Group between groups. The former smokers were significantly older when compared to never smokers and current smokers (66.5 ± 13.17 57.4 ± 7.82 63.7 ± 13.80, = 0.011). Former smokers and current smokers had a higher recurrence rate compared to never smokers (30.8% and 20.8% compared to zero, = 0.009). There was not a significant difference in recurrence between former smokers and current smokers. There was no difference in the mortality, non-response rate, or time to death between the groups.
Our data contributes evidence that cigarette smoking status is associated with increased recurrence for patients with anal cancer.
在美国，肛门癌的发病率一直在上升。吸烟是一个已被充分证实的风险因素；然而，吸烟对疾病复发和预后的影响尚未得到充分研究。本研究的目的是评估肛门癌复发与吸烟之间的关联。
探讨吸烟状况与肛门癌治疗结果之间的关系。
对一家社区医院2010年至2021年期间肛门癌患者的癌症登记资料进行筛查。从数据库中收集以下特征：年龄；性别；吸烟史；美国癌症联合委员会临床分期组；治疗反应；复发；复发时间；死亡率；死亡时间；以及随访时间。患者被分为以下几组：当前吸烟者；既往吸烟者；从不吸烟者。使用SPSSv25.0软件（美国纽约州阿蒙克市IBM公司）进行统计分析。
数据库中共有95名患者符合筛查标准。其中37名从不吸烟者，22名既往吸烟者，36名当前吸烟者。各组在种族或性别方面没有差异。各组在美国癌症联合委员会临床分期组方面没有差异。与从不吸烟者和当前吸烟者相比，既往吸烟者年龄显著更大（分别为66.5±13.17、57.4±7.82、63.7±13.80，P = 0.011）。与从不吸烟者相比，既往吸烟者和当前吸烟者的复发率更高（分别为30.8%和20.8%，从不吸烟者为零，P = 0.009）。既往吸烟者和当前吸烟者之间的复发率没有显著差异。各组在死亡率、无反应率或死亡时间方面没有差异。
我们的数据提供了证据，表明吸烟状况与肛门癌患者复发率增加有关。
