Holmes F, Borek D, Owen-Kummer M, Hassanein R, Fishback J, Behbehani A, Baker A, Holmes G
Department of Biometry, University of Kansas Medical Center, Kansas City.
Gastroenterology. 1988 Jul;95(1):107-11. doi: 10.1016/0016-5085(88)90297-1.
We studied predisposing factors in 56 women with anal cancer, comparing them with 56 matched controls drawn from the population. A detailed pretested questionnaire was administered to each study subject in a structured interview and blood was drawn for detection of herpes simplex virus antibodies by radioimmunoassay. Pathologic material from cases was obtained and evidence of human papilloma virus infection was sought. By univariate analyses we found associations between anal cancer and positive herpes simplex virus 2 titer (p = 0.0017), cigarette smoking (p = 0.0028), previous positive or questionable cervical Papanicolaou smear (p = 0.0124), and increasing number of sexual partners (p = 0.0224). By the multivariate technique of logistic regression there were independent and significant associations with cigarette smoking (p = 0.0126), previous use of hemorrhoid preparations (p = 0.0149), and history of disturbed bowel habits for greater than 1 mo (p = 0.0273). Anal cancer in women is a rare disease associated with cigarette smoking and sexual experience. Its association with previous anorectal disease is unclear and deserving of further study.
我们研究了56例患肛管癌的女性的易感因素，并将她们与从人群中选取的56例匹配对照进行比较。通过结构化访谈，向每位研究对象发放一份经过预测试的详细问卷，并采集血液，通过放射免疫测定法检测单纯疱疹病毒抗体。获取病例的病理材料，查找人乳头瘤病毒感染的证据。通过单变量分析，我们发现肛管癌与单纯疱疹病毒2滴度阳性（p = 0.0017）、吸烟（p = 0.0028）、既往宫颈巴氏涂片阳性或可疑（p = 0.0124）以及性伴侣数量增加（p = 0.0224）之间存在关联。通过逻辑回归的多变量技术分析发现，吸烟（p = 0.0126）、既往使用过痔疮制剂（p = 0.0149）以及肠道习惯紊乱超过1个月的病史（p = 0.0273）存在独立且显著的关联。女性肛管癌是一种与吸烟和性经历相关的罕见疾病。其与既往肛肠疾病的关联尚不清楚，值得进一步研究。
