Akın Öztürk Güliz, Ermiş Gizem, Eskicioğlu Emre, Güdücü Çağdaş
Department of Biophysics, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey.
Turk Arch Otorhinolaryngol. 2023 Mar;61(1):37-42. doi: 10.4274/tao.2023.2023-1-6. Epub 2023 Aug 11.
Olfaction is critical for maintaining daily life activities. It is crucial to measure olfactory performance for the diagnosis and treatment of certain neurodegenerative diseases. Moreover, impairments and a lack of quality in the olfactory system may indicate the early diagnosis of some diseases such as Parkinson's. In this context, there are several imaging methods available for evaluating olfactory function. In addition to the conventional methods used in measuring the brain's responsiveness to olfactory stimuli, this article presents a systematic review of the current applicability of optical brain imaging (i.e., functional near-infrared spectroscopy) in the evaluation of olfactory function. A database literature search was conducted in PubMed, Scopus, the Web of Science, and ScienceDirect. This review excluded animal studies, clinical studies, pathology- or neurodegenerative disease-related studies, newborn-related studies, cross-modal- and dual-task-related studies, and non-original research studies. Thus, seven studies were examined to discuss the pitfalls and perspectives of the use of optical brain imaging under olfactory stimulation. As for this conclusion, they can be used to evaluate olfactory performance in healthy individuals through the interpretation of hemodynamic changes. Further studies are needed to standardize the applicability of these optical imaging techniques.
嗅觉对于维持日常生活活动至关重要。测量嗅觉功能对于某些神经退行性疾病的诊断和治疗至关重要。此外，嗅觉系统的损伤和质量缺失可能预示着一些疾病（如帕金森病）的早期诊断。在此背景下，有几种成像方法可用于评估嗅觉功能。除了用于测量大脑对嗅觉刺激反应性的传统方法外，本文还对光学脑成像（即功能近红外光谱）在嗅觉功能评估中的当前适用性进行了系统综述。在PubMed、Scopus、科学网和ScienceDirect中进行了数据库文献检索。本综述排除了动物研究、临床研究、病理学或神经退行性疾病相关研究、新生儿相关研究、跨模态和双任务相关研究以及非原创性研究。因此，共审查了七项研究，以讨论在嗅觉刺激下使用光学脑成像的陷阱和前景。至于这一结论，它们可通过对血流动力学变化的解读来评估健康个体的嗅觉表现。需要进一步研究来规范这些光学成像技术的适用性。
