Department of Pharmaceutical Science & Technology, College of Biology & Medical Engineering, Donghua University, Shanghai, 201620, China.
Dongfang Hepatobiliary Surgery Hospital, Shanghai, 200433, China.
Nanomedicine (Lond). 2023 Jun;18(14):987-1002. doi: 10.2217/nnm-2023-0112. Epub 2023 Aug 10.
We prepared (PG) aqueous fruit extract, utilized it to synthesize silver nanoparticles (PG-Ag NPs) and evaluated the antibacterial and anticancer activities of the nanoparticles (NPs). Silver nitrate aqueous solution was reduced to PG-Ag NPs using aqueous PG fruit extract. NP shape, size, composition and functionalization were determined using transmission electron microscopy, x-ray photoelectron spectroscopy, Fourier transform infrared and x-ray diffraction. PG-Ag NPs were spherical, approximately 39-77 nm-sized, functionalized surfaces with notable antibacterial activity against both and , with an MIC <30 ug/ml and cytotoxicity toward esophageal cancer cells, with IC values less than 20 ug/ml. PG-Ag@rt NPs have been shown to be a potent antibacterial and anticancer agent, and their enriched particle surfaces can be conjugated with other compounds for multibiomedical applications.
我们制备了（PG）水提水果提取物，利用其合成了银纳米粒子（PG-Ag NPs），并评估了纳米粒子（NPs）的抗菌和抗癌活性。使用水提 PG 水果提取物将硝酸银水溶液还原为 PG-Ag NPs。通过透射电子显微镜、X 射线光电子能谱、傅里叶变换红外和 X 射线衍射确定了 NP 的形状、尺寸、组成和功能化。PG-Ag NPs 呈球形，尺寸约为 39-77nm，表面功能化，对 和 均具有显著的抗菌活性，MIC<30μg/ml，对食管癌细胞具有细胞毒性，IC 值小于 20μg/ml。PG-Ag@rt NPs 已被证明是一种有效的抗菌和抗癌药物，其富含粒子的表面可以与其他化合物结合，用于多生物医学应用。
