Molecular Medicine and Cancer Therapeutics Lab, Department of Zoology, Faculty of Science and Technology, University of Central Punjab, Lahore, Pakistan.
Department of Zoology, Faculty of Science and Technology, Environmental Health and Wildlife, University of Central Punjab, Lahore, Pakistan.
Environ Sci Pollut Res Int. 2023 Sep;30(42):95077-95085. doi: 10.1007/s11356-023-29273-3. Epub 2023 Aug 16.
Microplastics (MPs) are biologically active environmental pollutants having significant impact on the ecosystem and human health. MPs have been reported to increase oxidative stress, resulting in tissue damage, developmental abnormalities, metabolic disorders, epigenetic changes, abnormal reproduction, and reduced gamete quality. At present, most of the existing literature has focused on the effects of MPs on the reproduction of various aquatic organisms; however, the effects of MPs on mammalian reproduction specifically humans are least studied except a few ones fragmentally discussing the effects of MPs on gametogenesis in human. This review discusses effects of MPs on male and female reproduction with a focus on different metabolic pathways involved in compromised gamete quality, gamete toxicity, apoptosis, and DNA damage.
微塑料（MPs）是具有生物活性的环境污染物，对生态系统和人类健康有重大影响。已有报道称，微塑料会增加氧化应激，导致组织损伤、发育异常、代谢紊乱、表观遗传改变、生殖异常和配子质量下降。目前，大多数现有文献都集中在 MPs 对各种水生生物生殖的影响上；然而，除了少数文献零散地讨论了 MPs 对人类配子发生的影响外，对 MPs 对哺乳动物生殖，特别是人类生殖的影响研究最少。本综述讨论了 MPs 对男性和女性生殖的影响，重点讨论了涉及配子质量受损、配子毒性、细胞凋亡和 DNA 损伤的不同代谢途径。
