Wu Yong-Jie, Wang Zhen-Kai, Jia Zhen-Sheng, Chen Jia-Hao, Huang Fan-Rui, Zhan Bei-Bei, Yao Qi-Jun, Shi Bing-Feng
Center of Chemistry for Frontier Technologies, Department of Chemistry, Zhejiang University, Hangzhou, 310027, China.
School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, 453007, China.
Angew Chem Int Ed Engl. 2023 Oct 2;62(40):e202310004. doi: 10.1002/anie.202310004. Epub 2023 Aug 28.
Highly efficient synthesis of axially chiral biaryl amines through cobalt-catalyzed atroposelective C-H arylation using easily accessible cobalt(II) salt and salicyloxazoline ligand has been reported. This methodology provides a straightforward and sustainable access to a broad range of enantioenriched biaryl-2-amines in good yields (up to 99 %) with excellent enantioselectivities (up to 99 % ee). The synthetic utility of the unprecedented method is highlighted by its scalability and diverse transformations.
据报道，使用易于获得的钴（II）盐和水杨基恶唑啉配体，通过钴催化的对映选择性C-H芳基化反应可高效合成轴手性联芳基胺。该方法提供了一种直接且可持续的途径，以良好的产率（高达99%）和优异的对映选择性（高达99% ee）获得多种对映体富集的联芳基-2-胺。这种前所未有的方法的合成实用性通过其可扩展性和多样的转化得到了突出体现。
