由均配型铁水杨醛肟配合物催化的对映选择性C-H胺化反应。

Stroek Wowa, Rowlinson Nathalie A V, Hudson Luke A, Albrecht Martin

Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, CH-3012 Bern, Switzerland.

Chem Commun (Camb). 2025 Sep 5. doi: 10.1039/d5cc04627k.

Iron complexes bearing chiral salicyloxazoline (Salox) ligands catalyze the enantioselective intramolecular C-H bond amination of alkyl azides, reaching 58-76% ee for benzylic C-H bonds. Further, for the first time aliphatic C-H bond amination is demonstrated (∼40% ee). This class of catalysts even activates primary aliphatic C-H bonds, albeit with moderate ee.

带有手性水杨基恶唑啉（Salox）配体的铁配合物催化叠氮烷基的对映选择性分子内C-H键胺化反应，苄基C-H键的对映体过量值（ee）达到58-76%。此外，首次证明了脂肪族C-H键的胺化反应（ee约为40%）。这类催化剂甚至能活化伯脂肪族C-H键，尽管对映体过量值适中。