Center of Reproductive Medicine and Center of Prenatal Diagnosis, First Hospital, Jilin University, Changchun, China.
J Int Med Res. 2023 Aug;51(8):3000605231187948. doi: 10.1177/03000605231187948.
This study aimed to compare the effects of two brands of commercial vitrification carriers on pregnancy outcomes in freeze-thaw cycles.
We included 4871 patients who underwent a "freeze all" strategy using the commercial carriers J.Y. straw and OYASHIPS straw in the Reproductive Center of the First Hospital of Jilin University. The pregnancy outcomes of cleavage-stage embryos and blastocysts were studied separately. Detailed data and the safety of children born from mothers with the two types of carriers were also compared.
Patients who used J.Y. straw had similar clinical pregnancy and live birth rates with one and two cleavage-stage embryo transplantation to those who used OYASHIPS straw. In patients who had blastocyst transplantation, the clinical pregnancy rate of one blastocyst transplanted in those who used OYASHIPS straw was significantly higher than that in those who used J.Y. straw (57.85% vs 47.09%). Among children born from mothers who used J.Y. straw, the congenital disability rate was significantly higher than that in those with OYASHIPS straw.
The OYASHIPS straw carrier is cheap and can achieve clinical pregnancy and live birth outcomes comparable to those of J.Y. straw. Therefore, OYASHIPS straw is a good alternative option.
本研究旨在比较两种商业玻璃化载剂在冻融周期中对妊娠结局的影响。
我们纳入了在吉林大学第一医院生殖中心采用商业载剂 J.Y. straw 和 OYASHIPS straw 进行“全冻”策略的 4871 名患者。分别研究了卵裂期胚胎和囊胚的妊娠结局。还比较了详细数据和来自使用两种载剂的母亲的儿童的安全性。
使用 J.Y. straw 的患者在进行一次和两次卵裂期胚胎移植时，其临床妊娠率和活产率与使用 OYASHIPS straw 的患者相似。在进行囊胚移植的患者中，使用 OYASHIPS straw 的患者移植一个囊胚的临床妊娠率明显高于使用 J.Y. straw 的患者（57.85% vs 47.09%）。使用 J.Y. straw 的母亲所生的儿童中，先天性残疾率明显高于使用 OYASHIPS straw 的母亲。
OYASHIPS straw 载剂价格低廉，可达到与 J.Y. straw 相当的临床妊娠和活产结局。因此，OYASHIPS straw 是一种很好的替代选择。
