Olson C E, Soll A H, Guth P H
Gastroenterology. 1986 Nov;91(5):1192-7. doi: 10.1016/s0016-5085(86)80016-6.
Circadian rhythms of physiologic processes allow coordination of interdependent functions and separation of incompatible functions. Several gastrointestinal processes, which potentially alter the balance between gastric mucosal protection and injury, show regular fluctuations. We investigated the possibility that susceptibility to gastric mucosal injury by acidified aspirin and absolute ethanol may vary with phases of the light/dark cycle in the rat. We found that acidified aspirin caused significantly more gastric mucosal lesions when administered early in the light phase compared with administration early in the dark phase. The differences in susceptibility were not altered by pretreatment conditions such as immobilization or length of the fasting period. Absolute ethanol also caused significantly greater gastric mucosal injury when administered in the light than in the dark phase, but this difference was only evident in rats immobilized during the pretreatment fasting period. In contrast to the acidified aspirin group, rats unrestrained during pretreatment fasting did not have light/dark differences in susceptibility to ethanol injury. We concluded that rats show circadian variation in susceptibility to gastric mucosal injury by acidified aspirin.
生理过程的昼夜节律能够协调相互依存的功能，并将不相容的功能区分开来。一些可能改变胃黏膜保护与损伤平衡的胃肠过程呈现出规律的波动。我们研究了大鼠对酸化阿司匹林和无水乙醇所致胃黏膜损伤的易感性是否会随明暗周期的不同阶段而变化。我们发现，与在暗期早期给药相比，在明期早期给予酸化阿司匹林会导致显著更多的胃黏膜损伤。预处理条件（如固定或禁食期的长短）并未改变易感性的差异。无水乙醇在明期给药时也比在暗期引起显著更严重的胃黏膜损伤，但这种差异仅在预处理禁食期固定的大鼠中明显。与酸化阿司匹林组不同，预处理禁食期间未受束缚的大鼠对乙醇损伤的易感性不存在明暗差异。我们得出结论，大鼠对酸化阿司匹林所致胃黏膜损伤的易感性存在昼夜变化。
