Larsen K R, Barattini P, Dayton M T, Moore J G
Department of Medicine, Salt Lake Veterans Affairs Medical Center, Utah 84148.
Dig Dis Sci. 1994 Apr;39(4):678-88. doi: 10.1007/BF02087408.
The effects of four weeks of continuous illumination (LL), a subacute stress, on gastric mucosal endogenous aggressive and defensive factors were studied. Young male Sprague-Dawley rats were used with two different illumination regimens: LL and 12 hr light/12 hr dark (LD). At the end of three to four weeks of either regimen of illumination, gastric acid secretion, pepsin secretion, mucus secretion, and potential difference (PD) were studied. All gastric parameters, except mucus secretion, were significantly reduced by LL. The reduction in acid secretion (13.3%) was not significant after Bonferroni correction for the four t tests Pepsin secretion and PD were 27.9% and 24.6% less, respectively. These differences were significant after Bonferroni correction. The LD rats showed significant circadian rhythms for acid, mucus, and pepsin secretion. The LL rats showed significant rhythmicity for these same parameters with period lengths different from 24 hr. Gross inspection of the gastric mucosa indicated that 69.8% of the LL rats had lesion scores of 1.0 or higher, while none of the LD rats had scores above 0.5.
研究了持续四周光照（LL）这一亚急性应激对胃黏膜内源性攻击和防御因子的影响。选用年轻雄性斯普拉格-道利大鼠，采用两种不同的光照方案：LL和12小时光照/12小时黑暗（LD）。在两种光照方案三到四周结束时，研究胃酸分泌、胃蛋白酶分泌、黏液分泌和电位差（PD）。除黏液分泌外，所有胃参数均因LL而显著降低。经Bonferroni校正后，四次t检验中胃酸分泌减少13.3%不显著。胃蛋白酶分泌和PD分别减少27.9%和24.6%。经Bonferroni校正后，这些差异显著。LD大鼠的胃酸、黏液和胃蛋白酶分泌表现出明显的昼夜节律。LL大鼠这些相同参数表现出明显的节律性，但其周期长度不同于24小时。胃黏膜大体检查表明，69.8%的LL大鼠病变评分为1.0或更高，而LD大鼠无一评分高于0.5。
