阿司匹林（ASA）诱导的禁食大鼠胃损伤中的昼夜节律

Circadian rhythm in aspirin (ASA)-induced injury to the stomach of the fasted rat.

作者信息

Larsen K R, Moore J G, Dayton M T, Yu Z

机构信息

Department of Medicine, Salt Lake Veterans Affairs Medical Center, Salt Lake City 84148.

出版信息

Dig Dis Sci. 1993 Aug;38(8):1435-40. doi: 10.1007/BF01308600.

DOI:10.1007/BF01308600

PMID:8344098

Abstract

Circadian rhythms exist in several gastric parameters affecting ulcerogenesis. This study investigated possible circadian rhythmicity in observed aspirin (ASA)-induced gastric lesions in the rat. In five experiments 183 rats were studied at 14 time points over a 24-hr period. Rats were adapted for three weeks on a 12-hr light schedule, fasted 18 hr, then given oral acidified ASA. One hour later, the rats were sacrificed, the stomachs were removed, stretched flat, photographed, scanned, and measured for percent area of gross lesions in the gastric corpus by computer planimetry. Cosinor rhythmometric analysis showed a significant (P < 0.001) rhythm. Mean of rhythm (MESOR) was 5.60 +/- 0.25% of total corpus. Amplitude was 25.89 +/- 6.07% of MESOR. Peak time (acrophase) was 1909 +/- 0101 hr after lights on. Thus, gastric vulnerability to ASA injury exhibited circadian rhythmicity with peak injury during the dark period in this species.

摘要

昼夜节律存在于影响溃疡形成的多个胃参数中。本研究调查了大鼠中观察到的阿司匹林（ASA）诱导的胃损伤中可能存在的昼夜节律性。在五个实验中，在24小时内的14个时间点对183只大鼠进行了研究。大鼠按照12小时光照时间表适应三周，禁食18小时，然后口服酸化的ASA。一小时后，处死大鼠，取出胃，展平，拍照，扫描，并通过计算机平面测量法测量胃体大体损伤的面积百分比。余弦节律分析显示出显著的（P < 0.001）节律。节律均值（MESOR）为胃体总面积的5.60 +/- 0.25%。振幅为MESOR的25.89 +/- 6.07%。峰值时间（峰相位）为开灯后1909 +/- 0101小时。因此，该物种的胃对ASA损伤的易感性表现出昼夜节律性，在黑暗期损伤达到峰值。