Eibach H W, Zippel H H
Geburtshilfe Frauenheilkd. 1986 Aug;46(8):495-500. doi: 10.1055/s-2008-1036244.
For an observation period of 19 years the authors compiled the relevant clinical and pathomorphological data of patients of the Department of Gynaecology of the University of Cologne to assess the epithelial alterations in the vulva. Particular attention was given to the simultaneous or earlier presence of other genital carcinomas and of genital precancerous growths, especially to the high coincidence rate of malignant and premalignant lesions of the cervix uteri. Metric measurements were performed on histological section preparations to determine the extent and dimensions of microinvasions, i.e. of microcarcinomas. Histological examination of the epithelial alterations adjacent to invasive vulvar carcinomas revealed a carcinoma in situ in only 35% of the cases, in contrast to the situation at the cervix uteri. No definite answer can as yet be given to the question of the concrete risk of malignant degeneration of the carcinoma in situ of the vulva.
在19年的观察期内，作者收集了科隆大学妇科患者的相关临床和病理形态学数据，以评估外阴上皮的改变。特别关注了其他生殖器癌和生殖器癌前病变的同时或早期出现情况，尤其是子宫颈恶性和癌前病变的高重合率。对组织切片标本进行了计量测量，以确定微侵袭（即微癌）的范围和大小。与子宫颈的情况相反，对外阴浸润性癌相邻上皮改变的组织学检查显示，仅35%的病例存在原位癌。关于外阴原位癌恶性变的具体风险问题，目前尚无明确答案。
