Tribbia G, Pezzica E, Buzzi A, Sonzogni A, Crescini C
Clinica Dermatologica V, Università degli Studi, Milano.
Minerva Ginecol. 1995 Dec;47(12):531-4.
The frequency and meaning of epithelial alterations adjacent to a vulvar invasive carcinoma are examined. In the period from 1986 to 1989, 37 cases of vulvar invasive carcinoma were observed in the Bergamo Hospital (Anatomopathology Institute of Bergamo) in women aged between 54-95 years operated for vulvectomy. The vulvar epithelium adjacent to the invasive carcinoma was studied in order to determine the frequency and the type of associated lesions. Two lesions seem to be meaningfully correlated to the vulvar carcinoma: the lichen sclerosus in 59% of cases and the VIN3 of differentiated type in 35%. The identification of these epithelial lesions can serve to select the cases with increased risk to develop invasive carcinoma.
对外阴浸润性癌旁上皮改变的频率及意义进行了研究。在1986年至1989年期间，贝加莫医院（贝加莫解剖病理学研究所）对54至95岁接受外阴切除术的女性中观察到37例外阴浸润性癌。对浸润性癌旁的外阴上皮进行研究，以确定相关病变的频率和类型。两种病变似乎与外阴癌有显著相关性：59%的病例为硬化性苔藓，35%的病例为分化型VIN3。识别这些上皮病变有助于筛选出发生浸润性癌风险增加的病例。
