Neeb U
Geburtshilfe Frauenheilkd. 1986 Aug;46(8):545-6. doi: 10.1055/s-2008-1036254.
After a combined bronchodilatory treatment of theophylline and terbutaline an intermittant fetal bigeminus is observed. The cardiotoxic changes disappear after days when treatment is stopped. After delivery the child is healthy. The slow disappearance of the arrhythmia is a result of the prolonged half-life of theophylline in the fetus. A combined therapy for asthma should be avoided. If this is not possible, regular cardiologic controls of the fetus should be carried out.
在使用茶碱和特布他林进行联合支气管扩张治疗后,观察到胎儿出现间歇性二联律。停止治疗几天后,心脏毒性改变消失。分娩后婴儿健康。心律失常缓慢消失是由于茶碱在胎儿体内半衰期延长所致。应避免哮喘的联合治疗。如果无法避免,应对胎儿进行定期心脏检查。