Pôle Pharmacie, Service Hospitalo-Universitaire de Pharmacie, CHU Rennes, 35000, Rennes, France.
Service de Néphrologie, CHU Rennes, 35000, Rennes, France.
Eur J Hosp Pharm. 2023 Dec 27;31(1):68-69. doi: 10.1136/ejhpharm-2023-003871.
Tacrolimus is a widely used immunosuppressant for the prevention of rejection after transplantation. In vitro studies suggest that interactions exist between spices and tacrolimus. We present the case of a renal transplant patient aged around 70 years who was treated with prednisone, mycophenolate-mofetil and tacrolimus. The patient had a pre-transplant dietary habit of consuming foods spiced with turmeric, curry and ginger. The following protocol was implemented in parallel with close monitoring of plasma tacrolimus concentrations: administration of 10 g/day of turmeric for 4 days, then 10 g/day of curry for 4 days and then 10 g/day of ginger for 4 days. No change in tacrolimus plasma concentrations during and after the implementation of the protocol was observed. The impact of turmeric, curry and ginger on plasma tacrolimus concentrations seems negligible in vivo although further studies are needed. A shared decision to test the impact of spice consumption in a patient with dietary habits involving these spices seems reasonable.
他克莫司是一种广泛用于预防移植后排斥反应的免疫抑制剂。体外研究表明，香料和他克莫司之间存在相互作用。我们报告了一例年龄在 70 岁左右的肾移植患者，该患者接受泼尼松、霉酚酸酯和他克莫司治疗。该患者在移植前有食用加姜黄、咖喱和姜的食物的饮食习惯。在密切监测血浆他克莫司浓度的同时，并行实施了以下方案：4 天内每天服用 10 克姜黄，然后 4 天内每天服用 10 克咖喱，然后 4 天内每天服用 10 克姜。在实施方案期间和之后，未观察到他克莫司血浆浓度的变化。尽管需要进一步研究，但姜黄、咖喱和姜对体内他克莫司血浆浓度的影响似乎可以忽略不计。对于有食用这些香料饮食习惯的患者，共同决定测试香料消费的影响似乎是合理的。
