Chen Zhuang, Wang Qiming, Liu Jinbo, Wang Wenkang, Yuan Weitang, Liu Yang, Sun Zhenqiang, Wang Chengzeng
Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Academy of Medical Sciences of Zhengzhou University, Zhengzhou, Henan 450001, China.
Genes Dis. 2023 Jan 19;11(1):176-188. doi: 10.1016/j.gendis.2022.12.011. eCollection 2024 Jan.
A pre-metastatic niche (PMN) is a protective microenvironment that facilitates the colonization of disseminating tumor cells in future metastatic organs. Extracellular vesicles (EVs) play a role in intercellular communication by delivering cargoes, such as noncoding RNAs (ncRNAs). The pivotal role of extracellular vesicle-derived noncoding RNAs (EV-ncRNAs) in the PMN has attracted increasing attention. In this review, we summarized the effects of EV-ncRNAs on the PMN in terms of immunosuppression, vascular permeability and angiogenesis, inflammation, metabolic reprogramming, and fibroblast alterations. In particular, we provided a comprehensive overview of the effects of EV-ncRNAs on the PMN in different cancers. Finally, we discussed the promising clinical applications of EV-ncRNAs, including their potential as diagnostic and prognostic markers and therapeutic targets.
前转移微环境（PMN）是一种保护性微环境，它有助于播散的肿瘤细胞在未来的转移器官中定植。细胞外囊泡（EVs）通过递送诸如非编码RNA（ncRNAs）等货物在细胞间通讯中发挥作用。细胞外囊泡衍生的非编码RNA（EV-ncRNAs）在PMN中的关键作用已引起越来越多的关注。在这篇综述中，我们从免疫抑制、血管通透性和血管生成、炎症、代谢重编程和成纤维细胞改变等方面总结了EV-ncRNAs对PMN的影响。特别是，我们全面概述了EV-ncRNAs在不同癌症中对PMN的影响。最后，我们讨论了EV-ncRNAs有前景的临床应用，包括它们作为诊断和预后标志物以及治疗靶点的潜力。
